INT254179

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.29
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17f) extracellular region (Il17f)
Anatomy Link Frequency
macrophages 1
endothelial cells 1
Th17 cells 1
epithelial cells 1
fibroblasts 1
Il17f (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 195 97.88 Very High Very High Very High
Crohn's disease 193 87.72 High High
Inflammation 146 81.04 Quite High
chemokine 17 36.88 Quite Low
rheumatoid arthritis 65 33.60 Quite Low
Arthritis 16 23.52 Low Low
Inflammatory mediators 15 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 216 94.76 High High
Asthma 105 92.28 High High
Targeted Disruption 16 90.52 High High
Disease 250 87.72 High High
INFLAMMATION 152 81.04 Quite High
Autoimmune Disease 5 79.20 Quite High
Eosinophilia 8 75.52 Quite High
Sprains And Strains 4 68.52 Quite High
Occupational Lung Diseases 4 66.96 Quite High
Ileal Diseases 20 43.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Localization (release) of IL-17F in fibroblasts
1) Confidence 0.49 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.61 Pain Relevance 0.25
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Localization (release) of IL-17F in endothelial cells
2) Confidence 0.17 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.61 Pain Relevance 0.25
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Localization (release) of IL-17F in macrophages
3) Confidence 0.17 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.61 Pain Relevance 0.25
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Localization (release) of IL-17F in epithelial cells
4) Confidence 0.17 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.61 Pain Relevance 0.25
Two other studies strongly suggest that such effects of TH17 cells seem to be mediated through release of IL-17A and IL-17F [82, 83].
Localization (release) of IL-17F
5) Confidence 0.12 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.69 Pain Relevance 0
Two of them, IL-17A and IL-17F, are secreted by Th17 cells.
Localization (secreted) of IL-17F in Th17 cells
6) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.16 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox