INT254188

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.46
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Irak1) nucleus (Irak1) kinase activity (Irak1)
cytoplasm (Irak1)
Anatomy Link Frequency
A20 2
neutrophils 1
Irak1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 122 94.00 High High
chemokine 9 91.68 High High
rheumatoid arthritis 77 91.36 High High
cytokine 115 90.56 High High
tolerance 43 74.40 Quite High
Arthritis 16 67.44 Quite High
Central nervous system 23 43.36 Quite Low
addiction 1 23.76 Low Low
Inflammatory mediators 8 16.24 Low Low
antagonist 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 39 99.92 Very High Very High Very High
Necrosis 13 99.68 Very High Very High Very High
Systemic Lupus Erythematosus 153 99.44 Very High Very High Very High
Aging 103 99.40 Very High Very High Very High
Autoimmune Disease 66 96.56 Very High Very High Very High
INFLAMMATION 142 94.00 High High
Rheumatoid Arthritis 78 91.36 High High
Disease 113 78.76 Quite High
Apoptosis 46 70.16 Quite High
Arthritis 21 67.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Currently, active research on this topic is concerned with negatively regulating molecules that activate TLR-dependent signaling, but what about activating some of the natural inhibitory proteins, such as Triad3A, MyD88s, SHP-1, IRAK-M, IRAK1c, IRF4, and A20?
Positive_regulation (activate) of IRAK1c in A20
1) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.64 Pain Relevance 0.08
Similarly, promoting the production or activity of the other endogenous TLR signaling inhibitors, Triad3A, MyD88s, SHP-1, IRAK1c, IRF4, or A20, could provide additional options for effective treatment for systemic autoimmunity.
Positive_regulation (promoting) of IRAK1c in A20 associated with autoimmune disease
2) Confidence 0.41 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.78 Pain Relevance 0.14
The intracellular signalling cascade of IL-1 is similar to that of the MyD88-dependant TLR cascade discussed previously and involves the induction of IRAK1, IRAK4, MyD88 and transforming growth factor-activated kinase (TAK)1 [26].
Positive_regulation (induction) of IRAK1
3) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.12 Pain Relevance 0.46
Honda and Taniguchi reported that type I IFN induction was mediated trough TLR signaling, which stimulated sequential activation of adaptors and kinases of the IRAK, IKK and TRAF families, and then leading to the activation of IRF5 and IRF7 [44], [45].
Positive_regulation (activation) of IRAK
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.23 Pain Relevance 0
The displacement of TLRs to lipid rafts in neutrophils is deficient with aging, leading to an alteration of IRAK activation (Fulop et al 2004).
Positive_regulation (activation) of IRAK in neutrophils associated with aging
5) Confidence 0.22 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.48 Pain Relevance 0.09
This event allows activation of the IL-1R-associated kinase (IRAK)/tumor necrosis factor receptor-associated factor 6 (TRAF6) pathway leading to nuclear translocation of the nuclear factor kappa beta (NF-?
Positive_regulation (activation) of IRAK associated with necrosis and cancer
6) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.20 Pain Relevance 0
In a previous report by Newton and colleagues, sequential waves of K63 Ub, followed by K48 ubiquitin modifications, were induced on IRAK1, following ligation of the IL-1 receptor (33).
Positive_regulation (induced) of IRAK1
7) Confidence 0.17 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0.10

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