INT254198

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.87
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk1, Mapk8) cytoplasm (Mapk1, Mapk8) cytosol (Mapk1, Mapk8)
signal transduction (Mapk1, Mapk8) nucleus (Mapk1, Mapk8) kinase activity (Mapk1, Mapk8)
Mapk1 (Mus musculus)
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 36 99.44 Very High Very High Very High
antagonist 4 97.44 Very High Very High Very High
Arthritis 15 94.64 High High
COX2 1 85.84 High High
rheumatoid arthritis 65 81.72 Quite High
chemokine 3 70.08 Quite High
cytokine 26 53.84 Quite High
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 45 99.44 Very High Very High Very High
Arthritis 18 94.64 High High
Rheumatoid Arthritis 65 81.72 Quite High
Apoptosis 2 80.32 Quite High
Death 4 58.80 Quite High
Disease 24 45.44 Quite Low
Necrosis 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MIF has been shown to be an endogenous antagonist of glucocorticoids (reviewed in [110,111]); by inhibiting the latter, MIF enhances the inflammatory state through p38 MAPK and MAPK phosphatase 1 (MKP1) [112], which in turn deactivates p38, JNK and ERK.
MAPK phosphatase 1 Positive_regulation (deactivates) of JNK associated with inflammation and antagonist
1) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.87 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox