INT254209

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Jak1, Stat3) nucleus (Jak1, Stat3) DNA binding (Stat3)
signal transducer activity (Stat3) cell proliferation (Stat3) signal transduction (Stat3)
Jak1 (Mus musculus)
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 65 93.12 High High
Inflammation 36 92.48 High High
Arthritis 15 83.04 Quite High
cytokine 26 52.16 Quite High
chemokine 3 27.60 Quite Low
COX2 1 20.00 Low Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 65 93.12 High High
INFLAMMATION 45 92.48 High High
Arthritis 18 87.08 High High
Disease Progression 2 85.28 High High
Disease 24 51.96 Quite High
Autoimmune Disease 2 26.56 Quite Low
Apoptosis 2 22.48 Low Low
Necrosis 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-10 binds to the IL-10R1/IL-10R2 receptor complex and recruits both Jak1 and Tyk2 to activate STAT3 [125].
Jak1 Positive_regulation (activate) of STAT3
1) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.84 Pain Relevance 0.33

General Comments

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