INT254210

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.39
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) signal transduction (Cxcr2) extracellular region (Ccl2)
plasma membrane (Cxcr2) intracellular (Cxcr2) cytoskeleton organization (Ccl2)
Anatomy Link Frequency
macrophages 1
monocytes 1
Cxcr2 (Mus musculus)
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 6 100.00 Very High Very High Very High
Inflammation 72 99.82 Very High Very High Very High
rheumatoid arthritis 130 96.40 Very High Very High Very High
COX2 2 94.24 High High
cytokine 52 89.68 High High
Arthritis 30 89.32 High High
antagonist 8 78.72 Quite High
Inflammatory mediators 14 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 90 99.82 Very High Very High Very High
Apoptosis 4 96.72 Very High Very High Very High
Rheumatoid Arthritis 130 96.40 Very High Very High Very High
Arthritis 36 89.32 High High
Disease 48 81.28 Quite High
Death 8 42.64 Quite Low
Necrosis 12 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, MIF recruits monocytes/macrophages to the site of inflammation through CCL2 induction [117], or acting as a chemokine ligand on endothelial cell surfaces by directly binding to CXCR2 [118].


CXCR2 Binding (binding) of CCL2 in macrophages associated with chemokine and inflammation
1) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.20 Pain Relevance 0.63
Finally, MIF recruits monocytes/macrophages to the site of inflammation through CCL2 induction [117], or acting as a chemokine ligand on endothelial cell surfaces by directly binding to CXCR2 [118].


CXCR2 Binding (binding) of CCL2 in monocytes associated with chemokine and inflammation
2) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 1.20 Pain Relevance 0.63

General Comments

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