INT254219

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Myd88, Tlr2) plasma membrane (Myd88, Tlr2) intracellular (Myd88, Tlr2)
cytoplasm (Myd88, Tlr2) cytosol (Myd88) protein complex (Myd88)
Anatomy Link Frequency
plasma 1
Myd88 (Mus musculus)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 65 78.16 Quite High
Inflammation 44 70.24 Quite High
cytokine 48 65.76 Quite High
Inflammatory response 4 65.36 Quite High
Inflammatory mediators 7 62.76 Quite High
Arthritis 15 52.32 Quite High
antagonist 6 46.64 Quite Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 65 78.16 Quite High
Targeted Disruption 13 77.44 Quite High
Arthritis 18 70.72 Quite High
Pressure And Volume Under Development 2 65.92 Quite High
INFLAMMATION 55 65.00 Quite High
Shock 3 53.52 Quite High
Death 7 47.68 Quite Low
Myocardial Infarction 27 41.84 Quite Low
Disease 30 12.96 Low Low
Injury 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MyD88-dependent signalling via TLR2 and TLR4 requires the presence of TIRAP and will end after several steps in activation of NF?
MyD88-dependent Binding (signalling) of TLR2
1) Confidence 0.16 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.05 Pain Relevance 0.03
To date, Mal is thought to function as a sorting adaptor for TLR2 and TLR4, recruiting MyD88 to the receptor complex in the plasma membrane, through its ability to interact with phosphatidylinositol-4,5-bisphosphate [42] (Figure 1).
MyD88 Binding (recruiting) of TLR2 in plasma
2) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.55 Pain Relevance 0.16

General Comments

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