INT254242

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, DKK1) extracellular space (TNF, DKK1) extracellular region (TNF, DKK1)
plasma membrane (TNF, DKK1) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
DKK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1 100.00 Very High Very High Very High
spinal inflammation 75 85.16 High High
Inflammation 66 82.24 Quite High
imagery 35 80.24 Quite High
spondylitis 6 68.68 Quite High
Infliximab 3 57.92 Quite High
rheumatoid arthritis 2 37.80 Quite Low
cINOD 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteophyte 1 98.12 Very High Very High Very High
Osteoporosis 1 97.92 Very High Very High Very High
INFLAMMATION 99 85.16 High High
Low Back Pain 49 77.36 Quite High
Ankylosis 2 67.84 Quite High
Disease 5 44.80 Quite Low
Rheumatoid Arthritis 2 37.80 Quite Low
Necrosis 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Rheumatic Diseases 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF and other proinflammatory cytokines are known to promote bone formation by upregulating the expression of Dickkopf-1, a key target gene of TNF and an inhibitor of osteophyte regulators [29].
TNF Positive_regulation (upregulating) of Gene_expression (expression) of Dickkopf-1 associated with osteophyte and cytokine
1) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592781 Disease Relevance 1.24 Pain Relevance 0.91

General Comments

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