INT254253

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.60
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighm)
Ighm (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 105 98.96 Very High Very High Very High
Osteoarthritis 42 98.68 Very High Very High Very High
Arthritis 4 26.96 Quite Low
Inflammation 23 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypergammaglobulinemia 4 99.78 Very High Very High Very High
Rheumatoid Arthritis 105 98.96 Very High Very High Very High
Targeted Disruption 42 98.90 Very High Very High Very High
Frailty 47 98.68 Very High Very High Very High
Disease 62 96.44 Very High Very High Very High
Keratoconjunctivitis 1 94.44 High High
Salivary Gland Disease 20 89.24 High High
Syndrome 80 85.16 High High
Systemic Lupus Erythematosus 11 77.96 Quite High
Autoimmune Disease 14 71.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within the group of the IgM positive sera 94% (n?
Transcription (group) of IgM
1) Confidence 0.45 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0.12 Pain Relevance 0
10) of all IgM positive vaccinees, a decline of the IgM titre was observed while the IgG titre was constant until the last analysis.
Transcription (observed) of IgM
2) Confidence 0.45 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0 Pain Relevance 0
3) of these vaccinees the IgM reaction was detectable before the IgG response.
Transcription (detectable) of IgM
3) Confidence 0.45 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0 Pain Relevance 0
BAFF Tg mice also had severe hypergammaglobulinemia with high levels of immunoglobulins, specifically IgG, IgM, IgA, and IgE isotypes; however, neither anti-SSA/Ro or anti-SSB/La autoantibodies were detected [79].
Transcription (levels) of IgM associated with targeted disruption and hypergammaglobulinemia
4) Confidence 0.31 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.71 Pain Relevance 0
To distinguish between these two possibilities, qPCR was used to determine mRNA levels for constant regions of IgM and IgG1 heavy chains in RA and OA synovia.
Spec (determine) Transcription (levels) of IgM associated with rheumatoid arthritis and osteoarthritis
5) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 1.71 Pain Relevance 0.78
Rituximab significantly reduced immunoglobulin production at the mRNA level, as well as total IgM and IgG content in synovia containing lymphoid aggregates, but not in synovia where lymphoid infiltration was diffuse.
Transcription (level) of IgM
6) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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