INT254254

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (C6orf25) endoplasmic reticulum (C6orf25) plasma membrane (C6orf25)
C6orf25 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 51 52.24 Quite High
alcohol 1 49.60 Quite Low
Arthritis 1 23.76 Low Low
Osteoarthritis 21 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Antihistamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Agammaglobulinemia 10 90.84 High High
Bacterial Infection 11 81.52 Quite High
Disease 24 76.40 Quite High
Syndrome 1 59.68 Quite High
Anaphylaxis 1 53.52 Quite High
Rheumatoid Arthritis 51 52.24 Quite High
Immunodeficiency 4 50.00 Quite Low
Infection 9 30.60 Quite Low
Pneumonia 3 26.96 Quite Low
Arthritis 1 23.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following Bruton’s initial description of the beneficial effects of antibody replacement in a patient with severe deficiency in immunoglobulin production, intramuscular dosing became the primary route of administration.
Negative_regulation (deficiency) of Gene_expression (production) of immunoglobulin
1) Confidence 0.30 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.49 Pain Relevance 0
Rituximab significantly reduced immunoglobulin production at the mRNA level, as well as total IgM and IgG content in synovia containing lymphoid aggregates, but not in synovia where lymphoid infiltration was diffuse.
Negative_regulation (reduced) of Gene_expression (production) of immunoglobulin
2) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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