INT254269

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 17
Disease Relevance 13.29
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17f) extracellular region (Il17f)
Anatomy Link Frequency
Th17 cells 5
memory T cells 2
immune cells 1
epithelial cells 1
goblet cell 1
Il17f (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 577 100.00 Very High Very High Very High
Inflammation 335 99.16 Very High Very High Very High
dexamethasone 5 98.30 Very High Very High Very High
Inflammatory stimuli 3 98.24 Very High Very High Very High
rheumatoid arthritis 298 98.08 Very High Very High Very High
Multiple sclerosis 161 96.32 Very High Very High Very High
Arthritis 452 94.00 High High
Crohn's disease 313 89.44 High High
chemokine 41 82.92 Quite High
Inflammatory mediators 13 81.52 Quite High
Disease Link Frequency Relevance Heat
Candida Infection 48 99.52 Very High Very High Very High
INFLAMMATION 323 99.16 Very High Very High Very High
Asthma 313 98.80 Very High Very High Very High
Colon Disease 6 98.48 Very High Very High Very High
Rheumatoid Arthritis 298 98.08 Very High Very High Very High
Autoimmune Disease 85 96.92 Very High Very High Very High
Inflammatory Bowel Disease 327 96.80 Very High Very High Very High
Demyelinating Disease 178 96.32 Very High Very High Very High
Infection 55 95.44 Very High Very High Very High
Eosinophilia 24 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed increase in expression levels of IL17A, IL17F, IL22 and IL26 and the downstream proinflammatory cytokines IL6 and IL1?
Gene_expression (expression) of IL17F associated with cytokine
1) Confidence 0.48 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.90 Pain Relevance 0.44
The expression levels of the Th17 effector cytokines IL17A, IL17F, IL21, IL22 and IL26 were comparable between colonic and ileal control samples (Figure 1B); however, the expression of these cytokines in each individual sample was not consistent.
Gene_expression (expression) of IL17F associated with cytokine
2) Confidence 0.37 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.44 Pain Relevance 0.50
The present study assessed the mRNA expression levels of Th17 effector cytokines (IL17A, IL17F, IL21, IL22 and IL26) and genes involved in differentiation (IL6, IL1B, TGFB1, IL23A and STAT3) and recruitment of Th17 cells (CCR6 and CCL20) by quantitative real-time PCR analysis of colonic and ileal biopsies from 22 healthy control subjects, 26 patients with Crohn's disease (CD) and 12 patients with ulcerative colitis (UC).
Gene_expression (expression) of IL17F in Th17 cells associated with inflammatory bowel disease, crohn's disease, disease and cytokine
3) Confidence 0.37 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.87 Pain Relevance 0.34
Increased expression of IL17A, IL17F, IL22, IL26, IL21, CCL20 and CCR6 has been found in inflamed colonic tissues of IBD patients [4,14,28-33].
Gene_expression (expression) of IL17F associated with inflammatory bowel disease
4) Confidence 0.37 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.62 Pain Relevance 0.31
Although increased expression of IL17A, IL17F, IL21 and IL26 was detected in inflamed ileal samples, expression of the indispensable Th17 cell differentiation factors TGFB1 and IL23A, the signaling molecule STAT3 and the Th17 recruitment factors CCR6 and CCL20 were unchanged.


Gene_expression (expression) of IL17F in Th17 cell
5) Confidence 0.37 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.89 Pain Relevance 0.33
The expression levels of the Th17 effector cytokines IL17A, IL17F, IL21, IL22 and IL26 were comparable between colonic and ileal control samples (Figure 1B); however, the expression of these cytokines in each individual sample was not consistent.
Gene_expression (expression) of IL17F associated with cytokine
6) Confidence 0.37 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.45 Pain Relevance 0.49
Increased expression of IL-17F has already been detected in asthmatic patients after allergen challenge.
Gene_expression (expression) of IL-17F associated with asthma
7) Confidence 0.11 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.59 Pain Relevance 0.16
These cells are identified as Th17 cells since they express CCR6, IL-17F, IL-22, IL-26, RORc, CCL20, low T-bet, low FoxP3, and low IFN-gamma.
Gene_expression (express) of IL-17F in Th17 cells
8) Confidence 0.10 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.84 Pain Relevance 0.46
Pulmonary overexpression of IL-17F in mice resulted not only in airway neutrophilia but also in an amplified allergen-induced immune-response including increased airway eosinophilia, AHR, and goblet cell hyperplasia [83].
Gene_expression (overexpression) of IL-17F in goblet cell associated with hyperplasia and eosinophilia
9) Confidence 0.09 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.64 Pain Relevance 0.20
In vitro restimulation of these cells resulted in production of IL-17A and IL-17F, IL-22, IL-26, lymphotoxin ?
Gene_expression (production) of IL-17F
10) Confidence 0.09 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.96 Pain Relevance 0.10
Interestingly, 1,25-(OH)2D3, in contrast to dexamethasone, directly modulated human Th17 polarization accompanied with suppression of IL-17A, IL-17F, TNF-alpha, and IL-22 production by FACS sorted memory T cells from these early RA patients [14].


Gene_expression (production) of IL-17F in memory T cells associated with rheumatoid arthritis and dexamethasone
11) Confidence 0.08 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.10 Pain Relevance 0.63
In CD4+ T cells from naïve and collagen-type II immunized DBA/1 mice, IL-23 increased the expression of IL-17A, IL-17F, and RORgammat.
Gene_expression (expression) of IL-17F in T cells
12) Confidence 0.08 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.49 Pain Relevance 0.10
Of note, IL-17A was produced mainly in T cells, whereas IL-17F was produced in T cells, innate immune cells, and epithelial cells [31].
Gene_expression (produced) of IL-17F in immune cells
13) Confidence 0.08 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.84 Pain Relevance 0.44
Th17 cells produce IL-17A and IL-17F, which are upregulated in chronic lesions [172, 173], and IL-22 which is also involved in MS pathogenesis.
Gene_expression (produce) of IL-17F in Th17 cells associated with multiple sclerosis
14) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.47 Pain Relevance 0.42
plus an inflammatory stimuli in the human, then the resulting clonal memory T-cell population will be instructed to produce the Th17 signature cytokines IL-17A, IL-17F, IL-22, and IL-26 (there is no mouse IL-26).
Gene_expression (produce) of IL-17F in memory T-cell associated with cytokine and inflammatory stimuli
15) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.56 Pain Relevance 0.45
Of note, IL-17A was produced mainly in T cells, whereas IL-17F was produced in T cells, innate immune cells, and epithelial cells [31].
Gene_expression (produced) of IL-17F in epithelial cells
16) Confidence 0.03 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.84 Pain Relevance 0.44
Th17 cells produce the cytokines IL-17A, IL-17F, IL-21, and IL-22 [81].
Gene_expression (produce) of IL-17F in Th17 cells associated with cytokine
17) Confidence 0.02 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.79 Pain Relevance 0.20

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