INT254280

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4, Tnfsf11) extracellular region (Il4, Tnfsf11) cell differentiation (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
endothelial cells 3
osteoblasts 1
Il4 (Mus musculus)
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 6 100.00 Very High Very High Very High
cytokine 46 97.08 Very High Very High Very High
Arthritis 36 86.88 High High
Inflammation 36 82.64 Quite High
rheumatoid arthritis 50 44.80 Quite Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 46 86.88 High High
Hypercalcemia 12 86.40 High High
INFLAMMATION 34 82.64 Quite High
Osteoporosis 8 78.24 Quite High
Rheumatoid Arthritis 50 44.80 Quite Low
Disease 18 25.28 Quite Low
Pressure And Volume Under Development 10 14.56 Low Low
Synovitis 10 5.00 Very Low Very Low Very Low
Nervous System Inflammation 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-4 and IL-13 promote expression of the natural RANKL antagonist, osteo-protegerin, by endothelial cells and osteoblasts [81,85].
IL-4 Positive_regulation (promote) of Gene_expression (expression) of natural RANKL antagonist in endothelial cells associated with antagonist
1) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.39 Pain Relevance 0.27
IL-4 and IL-13 promote expression of the natural RANKL antagonist, osteo-protegerin, by endothelial cells and osteoblasts [81,85].
IL-4 Positive_regulation (promote) of in osteoblasts Gene_expression (expression) of natural RANKL antagonist in endothelial cells associated with antagonist
2) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.39 Pain Relevance 0.27

General Comments

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