INT2543

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Context Info
Confidence 0.70
First Reported 1977
Last Reported 2010
Negated 27
Speculated 30
Reported most in Abstract
Documents 787
Total Number 819
Disease Relevance 331.13
Pain Relevance 592.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
plasma 74
neurons 53
DRG 49
nerve 32
spinal cord 21
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 7350 100.00 Very High Very High Very High
qutenza 2452 100.00 Very High Very High Very High
Pain 1941 100.00 Very High Very High Very High
Inflammation 1256 100.00 Very High Very High Very High
substance P 1247 100.00 Very High Very High Very High
Spinal cord 985 100.00 Very High Very High Very High
Neuropeptide 926 100.00 Very High Very High Very High
dorsal root ganglion 882 100.00 Very High Very High Very High
antagonist 660 100.00 Very High Very High Very High
Dorsal horn 415 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2223 100.00 Very High Very High Very High
Pain 1872 100.00 Very High Very High Very High
INFLAMMATION 1217 100.00 Very High Very High Very High
Arthritis 720 100.00 Very High Very High Very High
Nociception 673 100.00 Very High Very High Very High
Hyperalgesia 503 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 340 100.00 Very High Very High Very High
Nervous System Injury 181 100.00 Very High Very High Very High
Acidosis 144 100.00 Very High Very High Very High
Hypertension 107 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the myositis group, CGRP-LI was increased in the pituitary gland concomitant with the increase in CGRP-LI in the masseter muscles but was decreased in the hypothalamus.
Positive_regulation (increase) of CGRP in pituitary gland
1) Confidence 0.70 Published 2004 Journal J Orofac Pain Section Body Doc Link 15509004 Disease Relevance 0.06 Pain Relevance 0
In SHR and WKY preparations, PNS (4 and 8 Hz) evoked a frequency-dependent increase of CGRP-LI in the perfusate, which was abolished by 500 nM tetrodotoxin and the removal of Ca2+ from the medium.
Positive_regulation (increase) of CGRP associated with tetrodotoxin and calcitonin gene-related peptide
2) Confidence 0.70 Published 1992 Journal Clin Exp Hypertens A Section Abstract Doc Link 1424225 Disease Relevance 0.16 Pain Relevance 0.48
In the myositis group, CGRP-LI was increased in the pituitary gland concomitant with the increase in CGRP-LI in the masseter muscles but was decreased in the hypothalamus.
Positive_regulation (increased) of CGRP in pituitary gland
3) Confidence 0.70 Published 2004 Journal J Orofac Pain Section Body Doc Link 15509004 Disease Relevance 0.06 Pain Relevance 0
The gangliosym-pathectomy abolished the increase in the CGRP levels.
Positive_regulation (increase) of CGRP associated with calcitonin gene-related peptide
4) Confidence 0.70 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8957683 Disease Relevance 0 Pain Relevance 1.48
Stimulation-induced morphological alterations of perivascular terminals may represent a structural basis of increased CGRP content in jugular blood which follows electrical stimulation of the Gasserian ganglion and accompanies migraine attacks.
Positive_regulation (increased) of CGRP in blood associated with ganglion cysts, migraine and calcitonin gene-related peptide
5) Confidence 0.70 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7715843 Disease Relevance 0.59 Pain Relevance 0.41
Increased calcitonin gene-related peptide (CGRP), substance P, and enkephalin immunoreactivities in dorsal spinal cord and loss of CGRP-immunoreactive motoneurons in arthritic rats depend on intact peripheral nerve supply.
Positive_regulation (Increased) of calcitonin gene-related peptide in dorsal associated with enkephalin, arthritis, spinal cord, substance p and calcitonin gene-related peptide
6) Confidence 0.70 Published 1991 Journal J. Mol. Neurosci. Section Title Doc Link 1715733 Disease Relevance 0.46 Pain Relevance 1.37
Increased calcitonin gene-related peptide (CGRP), substance P, and enkephalin immunoreactivities in dorsal spinal cord and loss of CGRP-immunoreactive motoneurons in arthritic rats depend on intact peripheral nerve supply.
Positive_regulation (Increased) of CGRP in dorsal associated with enkephalin, arthritis, spinal cord, substance p and calcitonin gene-related peptide
7) Confidence 0.70 Published 1991 Journal J. Mol. Neurosci. Section Title Doc Link 1715733 Disease Relevance 0.46 Pain Relevance 1.37
Carvedilol given intravenously at a dose of 0.3 mg/kg transiently decreased the mean arterial blood pressure (MABP) and increased renal tissue blood flow with increases in CGRP levels in plasma and kidney.
Positive_regulation (increases) of CGRP in blood associated with calcitonin gene-related peptide
8) Confidence 0.70 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14764656 Disease Relevance 0.16 Pain Relevance 0.70
After the tissue was treated with capsaicin, PNS didn't cause both the vasodilator response and the increase of CGRP-LI in the perfusate.
Positive_regulation (increase) of CGRP associated with qutenza and calcitonin gene-related peptide
9) Confidence 0.70 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2359517 Disease Relevance 0 Pain Relevance 1.04
In arthritic rats there was a bilateral increase of CGRP- and substance P-immunoreactive fibers and appearance of enkephalin-immunoreactive cell bodies in the dorsal horn of the lumbar (L4) spinal cord when compared to controls.
Positive_regulation (increase) of CGRP in dorsal horn associated with dorsal horn, enkephalin, arthritis, spinal cord, substance p and calcitonin gene-related peptide
10) Confidence 0.70 Published 1991 Journal J. Mol. Neurosci. Section Abstract Doc Link 1715733 Disease Relevance 0.47 Pain Relevance 1.19
The pronounced but reversible increases of brain CGRP levels suggest a strong but short-lasting activation of the peptide system.
Positive_regulation (increases) of CGRP in brain associated with calcitonin gene-related peptide
11) Confidence 0.70 Published 1989 Journal Regul. Pept. Section Abstract Doc Link 2516343 Disease Relevance 0.51 Pain Relevance 0.47
Pronounced increases in brain levels of calcitonin gene-related peptide after kainic acid induced seizures.
Positive_regulation (increases) of calcitonin gene-related peptide in brain associated with convulsion and calcitonin gene-related peptide
12) Confidence 0.70 Published 1989 Journal Regul. Pept. Section Title Doc Link 2516343 Disease Relevance 0.51 Pain Relevance 0.46
We have shown previously that estrogen increases calcitonin gene-related peptide (CGRP)-immunoreactive sensory innervation of the rat mammary gland, but it is not known if this occurs in other tissues.
Positive_regulation (increases) of calcitonin gene-related peptide in mammary gland associated with calcitonin gene-related peptide
13) Confidence 0.70 Published 2004 Journal Brain Res. Section Abstract Doc Link 15262205 Disease Relevance 0.09 Pain Relevance 0.24
We have shown previously that estrogen increases calcitonin gene-related peptide (CGRP)-immunoreactive sensory innervation of the rat mammary gland, but it is not known if this occurs in other tissues.
Positive_regulation (increases) of CGRP in mammary gland associated with calcitonin gene-related peptide
14) Confidence 0.70 Published 2004 Journal Brain Res. Section Abstract Doc Link 15262205 Disease Relevance 0.09 Pain Relevance 0.24
Changes in the mRNA for CGRP suggest that the increase in spinal content of iCGRP is due to an increase in synthesis of the peptide as the level of mRNA for CGRP is increased from 2 to 8 days after injection of CFA.
Positive_regulation (increased) of CGRP in spinal associated with calcitonin gene related peptide
15) Confidence 0.70 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846392 Disease Relevance 0.52 Pain Relevance 1.24
In accord with the relative tissue levels of the respective peptides, capsaicin (10(-8) to 10(-5) M) and K+ (120 mM) added to the perfusate resulted in a concentration-dependent increase in the levels of CGRP and NKA, and to a minor extent SP, in the perfusates.
Positive_regulation (increase) of CGRP associated with qutenza, substance p and calcitonin gene-related peptide
16) Confidence 0.70 Published 1992 Journal Peptides Section Abstract Doc Link 1377821 Disease Relevance 0 Pain Relevance 0.93
Sustained morphine induces plasticity in both primary afferents and spinal cord, including increased CGRP and dynorphin content.
Positive_regulation (increased) of CGRP in spinal cord associated with dynorphin, calcitonin gene-related peptide, spinal cord and morphine
17) Confidence 0.70 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12151554 Disease Relevance 0.11 Pain Relevance 1.85
These studies suggest that the bulbocavernosus/levator ani muscles from castrated rats produce a factor that increases levels of CGRP.
Positive_regulation (increases) of CGRP in levator ani associated with calcitonin gene-related peptide
18) Confidence 0.70 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0.24 Pain Relevance 0.61
Chronic naltrexone increased the levels of CGRP in the hypothalamus.
Positive_regulation (increased) of CGRP in hypothalamus associated with calcitonin gene-related peptide
19) Confidence 0.70 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1335576 Disease Relevance 0 Pain Relevance 1.51
The antimigraine drugs sumatriptan and dihydroergotamine block the development of plasma extravasation and ultrastructural changes, as well as plasma calcitonin gene-related peptide (CGRP) increase in the superior sagittal sinus following electrical trigeminal ganglion stimulation.
Positive_regulation (increase) of plasma calcitonin gene-related peptide in trigeminal ganglion associated with ganglion cysts, cluster headache, sumatriptan, trigeminal ganglion and calcitonin gene-related peptide
20) Confidence 0.70 Published 1992 Journal Pathol. Biol. Section Abstract Doc Link 1379707 Disease Relevance 0.60 Pain Relevance 0.58

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