INT25430

Context Info Confidence 0.24 First Reported 1989 Last Reported 1997 Negated 0 Speculated 2 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.57 Pain Relevance 0.43

nucleus (Gtf3a, Nppa) extracellular region (Nppa) RNA binding (Gtf3a) intracellular (Gtf3a) DNA binding (Gtf3a) cytoplasm (Nppa)

Anatomy Link Frequency renal nerves 1 kidney 1 Gtf3a (Rattus norvegicus) Nppa (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 12 96.80 anesthesia 1 76.64

Disease Link Frequency Relevance Heat Natriuresis 4 100.00 Diuresis 2 98.40 Body Weight 6 67.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The aim of the present study was to investigate the role of renal nerves and atrial natriuretic factor (ANF) in the mechanisms responsible for the diuresis and antinatriuresis induced by morphine in rats in a normal state of hydration.

factor Spec (investigate) Regulation (role) of ANF in renal nerves associated with diuresis, natriuresis and morphine

1) Confidence 0.24 Published 1997 Journal Kidney Blood Press. Res. Section Abstract Doc Link 9192906 Disease Relevance 0.39 Pain Relevance 0.35

We investigated the effect of atrial natriuretic factor (ANF) on aldosterone receptors in the kidney cytosol, because the binding of aldosterone to aldosterone receptors in the cytosol is considered a critical step of its action.

factor Spec (investigated) Regulation (effect) of ANF in kidney associated with natriuresis

2) Confidence 0.06 Published 1989 Journal Hypertension Section Abstract Doc Link 2522415 Disease Relevance 0.17 Pain Relevance 0.08

General Comments

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