INT254316

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 6.39
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
macrophages 1
monocyte 1
Msu (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 384 99.56 Very High Very High Very High
Inflammatory response 42 98.16 Very High Very High Very High
cytokine 77 96.52 Very High Very High Very High
chemokine 27 91.56 High High
Arthritis 26 68.76 Quite High
Inflammatory mediators 7 55.44 Quite High
Pain 10 33.28 Quite Low
agonist 5 20.48 Low Low
cINOD 15 9.60 Low Low
imagery 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 517 100.00 Very High Very High Very High
INFLAMMATION 428 99.56 Very High Very High Very High
Adhesions 5 93.44 High High
Death 15 85.12 High High
Sprains And Strains 5 82.36 Quite High
Dyslipidemia /

Combined Dyslipidemia

2 81.40 Quite High
Metabolic Syndrome 14 80.68 Quite High
Hypertension 18 80.32 Quite High
Insulin Resistance 2 79.76 Quite High
Hyperuricemia 84 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although these findings do not exclude a role for an unidentified co-receptor that may cooperate with TLRs, they strongly suggest that TLRs do not recognize MSU or calcium pyrophosphate dihydrate crystals and that TLR2 and TLR4 may not be crucial for MSU-induced inflammation as previously suggested [19].
MSU Neg (not) Binding (recognize) of associated with inflammation and crystal associated disease
1) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.99 Pain Relevance 0.20
The interactions between monocyte/macrophages with MSU do not appear to be so deadly, eliciting principally the secretion of proinflammatory cytokines.
MSU Binding (interactions) of in macrophages associated with crystal associated disease and cytokine
2) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.83 Pain Relevance 0.29
MSU crystallizes when its plasma concentration exceeds its solubility (around 7 mg/dl, or 420 ?
MSU Binding (crystallizes) of in plasma associated with crystal associated disease
3) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 1.33 Pain Relevance 0.25
Gout is a paradigm for acute sterile inflammation that is triggered by interactions between MSU microcrystals and the local tissue environment.
MSU Binding (interactions) of associated with inflammation and crystal associated disease
4) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.76 Pain Relevance 0.21
As uric acid is a weak acid, its main form in plasma is MSU, which has a maximum solubility of about 420 ?
MSU Binding (solubility) of in plasma associated with crystal associated disease
5) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 0.74 Pain Relevance 0.07
As uric acid is a weak acid, its main form in plasma is MSU, which has a maximum solubility of about 420 ?
MSU Binding (form) of in plasma associated with crystal associated disease
6) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 0.75 Pain Relevance 0.07
The interactions between monocyte/macrophages with MSU do not appear to be so deadly, eliciting principally the secretion of proinflammatory cytokines.
MSU Binding (interactions) of in monocyte associated with crystal associated disease and cytokine
7) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.83 Pain Relevance 0.29

General Comments

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