INT254317

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.13
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pycard) extracellular region (Pycard) intracellular (Pycard)
protein complex (Pycard) cytoplasm (Pycard)
Anatomy Link Frequency
BMDM 1
neutrophil 1
Pycard (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 22 99.24 Very High Very High Very High
Inflammation 106 87.52 High High
anakinra 3 78.88 Quite High
cytokine 33 75.04 Quite High
Central nervous system 3 66.64 Quite High
transdermal 7 50.00 Quite Low
Neuropeptide 5 46.72 Quite Low
imagery 9 35.68 Quite Low
chemokine 9 12.76 Low Low
Spinal cord 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peritonitis 7 99.90 Very High Very High Very High
Crystal Associated Disease 148 99.50 Very High Very High Very High
INFLAMMATION 131 99.06 Very High Very High Very High
Spinal Injuries 8 93.32 High High
Apoptosis 29 90.08 High High
Salmonella Infection 1 78.08 Quite High
Disease 13 76.20 Quite High
Spinal Cord Injury 29 75.80 Quite High
Death 16 73.76 Quite High
Syndrome 4 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, as shown in Figure 1, both Pycard and Casp2 were down-regulated.
Negative_regulation (regulated) of Pycard
1) Confidence 0.42 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 1.02 Pain Relevance 0
Samples were enumerated in an ELISPOT reader (Cellular Technology, Shaker Heights, OH) and the results shown as the number of ASC per 106 cells.
Negative_regulation (number) of ASC
2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.06 Pain Relevance 0
Moreover, MSU-induced peritonitis was decreased in ASC-deficient or caspase-1-deficient mice.
Negative_regulation (decreased) of ASC associated with peritonitis and crystal associated disease
3) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.63 Pain Relevance 0.04
Furthermore, in a murine model of gout in which MSU crystals were directly injected into the peritoneal cavity to elicit an inflammatory response, neutrophil influx was significantly reduced in ASC-deficient mice compared with wild-type mice [29].
Negative_regulation (reduced) of ASC in neutrophil associated with inflammatory response and crystal associated disease
4) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 1.29 Pain Relevance 0.38
To further establish which intracellular receptors and/or adaptor proteins are activated by Hz, we used BMDM from mice deficient in NLRP3, ASC or another NLR, NLRC4 (NLR containing CARD domain, also known as IPAF).
Negative_regulation (deficient) of ASC in BMDM
5) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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