INT25432

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Context Info
Confidence 0.37
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 2.90
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH) extracellular region (GHRH) cell-cell signaling (GHRH)
Anatomy Link Frequency
fat 2
pituitary 2
nucleus 2
body 2
GHRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 10 96.64 Very High Very High Very High
Pain scale 1 83.76 Quite High
agonist 34 83.00 Quite High
Clonidine 2 77.60 Quite High
Somatostatin 15 76.76 Quite High
Enkephalin 2 75.00 Quite High
pain labor 1 75.00 Quite High
carpal tunnel syndrome 2 71.28 Quite High
antagonist 38 59.04 Quite High
Opioid 5 36.08 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus-type I 1 99.36 Very High Very High Very High
Endometriosis (extended) 4 97.08 Very High Very High Very High
Pain 8 96.64 Very High Very High Very High
Diabetes Mellitus 32 96.48 Very High Very High Very High
Aging 26 95.88 Very High Very High Very High
Hypertrophy 4 88.12 High High
Cardiovascular Disease 3 75.84 Quite High
Labor Pain 1 75.00 Quite High
Death 4 72.84 Quite High
Carpal Tunnel Syndrome 2 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli; in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone.
Negative_regulation (attenuates) of Gene_expression (administration) of Exogenous growth hormone
1) Confidence 0.37 Published 1996 Journal Eur. J. Endocrinol. Section Abstract Doc Link 8590960 Disease Relevance 0 Pain Relevance 0.15
Orexin A in turn inhibits GHRH gene expression, thus limiting GH-dependent lipolysis [562].
Negative_regulation (inhibits) of Gene_expression (expression) of GHRH
2) Confidence 0.25 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.14 Pain Relevance 0.03
Decreases in growth hormone (GH) and insulin-like growth factor-I, estrogen deficiency in women, diminished testosterone in men, and loss of lean body mass, increased fat, and other changes consistent with hormone deficiencies occur during aging.
Negative_regulation (loss) of in fat Gene_expression (Decreases) of growth hormone in body associated with aging
3) Confidence 0.24 Published 2004 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 15304529 Disease Relevance 0.77 Pain Relevance 0.14
Decreases in growth hormone (GH) and insulin-like growth factor-I, estrogen deficiency in women, diminished testosterone in men, and loss of lean body mass, increased fat, and other changes consistent with hormone deficiencies occur during aging.
Negative_regulation (deficiency) of in fat Gene_expression (Decreases) of growth hormone in body associated with aging
4) Confidence 0.24 Published 2004 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 15304529 Disease Relevance 0.68 Pain Relevance 0.13
Arcuate-nucleus GHRH-gene expression also declined in these animals [236], indicating that GHS-R1a not only transduces GHRH release but also maintains GHRH gene transcription [237, 238].
Negative_regulation (declined) of Gene_expression (expression) of Arcuate-nucleus GHRH-gene in nucleus
5) Confidence 0.22 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.12 Pain Relevance 0.11
Recent studies have suggested a partial block in somatomedin (SM) production or growth hormone (GH) action in IDDM.
Spec (partial) Negative_regulation (block) of Gene_expression (production) of growth hormone associated with diabetes mellitus-type i
6) Confidence 0.16 Published 1985 Journal Diabetes Section Abstract Doc Link 3967801 Disease Relevance 0.34 Pain Relevance 0.14
Cortisol, human growth hormone, and prolactin levels were lowered during labor for the exercise-conditioned patients.
Negative_regulation (lowered) of Gene_expression (levels) of growth hormone
7) Confidence 0.15 Published 1989 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 2522737 Disease Relevance 0.35 Pain Relevance 0.43
These reductions in secretions are identified by a poor but widely recognized appellation, the “pauses”: menopause (decreased ovarian function), adrenopause (decreased adrenal function, especially with regard to dehydroepiandrosterone secretion), somatopause (decreased growth hormone production), andropause (decreased hypothalamic-pituitary testicular function with diminished testosterone availability and impaired spermatogenesis) (Lamberts 1997).
Negative_regulation (decreased) of Gene_expression (production) of growth hormone in pituitary associated with endometriosis (extended)
8) Confidence 0.05 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686330 Disease Relevance 0.50 Pain Relevance 0

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