INT254332

Context Info Confidence 0.22 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.41 Pain Relevance 0.07

plasma membrane (Bmpr2) kinase activity (Bmpr2) cytoplasm (Bmpr2)

Anatomy Link Frequency bone marrow 2 bladder 2 limb 2 Bmpr2 (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 35 72.32 Osteoarthritis 33 71.76 chemokine 2 40.04 cytokine 13 39.56 Inflammation 33 5.00 Arthritis 17 5.00 antagonist 5 5.00 Pain 5 5.00 Inflammatory mediators 2 5.00 Multiple sclerosis 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 5 99.88 Cancer 67 99.80 Fracture Healing 32 99.42 Transitional Cell Carcinoma 1 98.48 Obesity 8 96.96 Leukemia 5 92.36 Femoral Fractures 1 90.48 Prostate Cancer 6 87.80 Colon Cancer 7 83.96 Breast Cancer 3 77.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A significant association between loss of BMPR2 expression and tumor grade was found in bladder transitional cell carcinoma [54].

Negative_regulation (loss) of Gene_expression (expression) of BMPR2 in bladder associated with cancer and transitional cell carcinoma

1) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 1.66 Pain Relevance 0

Tsuji et al (2006) evaluated the role of BMP-2 in fracture healing by creating transgenic mice lacking limb specific expression of BMP-2.

Negative_regulation (lacking) of Gene_expression (expression) of BMP-2 in limb associated with targeted disruption and fracture healing

2) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.51 Pain Relevance 0

type I receptor and reduced expression of BMP-2, BMP-4, and BMP-6 when compared with bone marrow MSCs, supplementation with BMP-6 and TGF-?

Negative_regulation (reduced) of Gene_expression (expression) of BMP-2 in bone marrow

3) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.24 Pain Relevance 0.07

General Comments

This test has worked.