INT254332

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.41
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bmpr2) kinase activity (Bmpr2) cytoplasm (Bmpr2)
Anatomy Link Frequency
bone marrow 2
bladder 2
limb 2
Bmpr2 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 35 72.32 Quite High
Osteoarthritis 33 71.76 Quite High
chemokine 2 40.04 Quite Low
cytokine 13 39.56 Quite Low
Inflammation 33 5.00 Very Low Very Low Very Low
Arthritis 17 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 99.88 Very High Very High Very High
Cancer 67 99.80 Very High Very High Very High
Fracture Healing 32 99.42 Very High Very High Very High
Transitional Cell Carcinoma 1 98.48 Very High Very High Very High
Obesity 8 96.96 Very High Very High Very High
Leukemia 5 92.36 High High
Femoral Fractures 1 90.48 High High
Prostate Cancer 6 87.80 High High
Colon Cancer 7 83.96 Quite High
Breast Cancer 3 77.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant association between loss of BMPR2 expression and tumor grade was found in bladder transitional cell carcinoma [54].
Negative_regulation (loss) of Gene_expression (expression) of BMPR2 in bladder associated with cancer and transitional cell carcinoma
1) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 1.66 Pain Relevance 0
Tsuji et al (2006) evaluated the role of BMP-2 in fracture healing by creating transgenic mice lacking limb specific expression of BMP-2.
Negative_regulation (lacking) of Gene_expression (expression) of BMP-2 in limb associated with targeted disruption and fracture healing
2) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.51 Pain Relevance 0
type I receptor and reduced expression of BMP-2, BMP-4, and BMP-6 when compared with bone marrow MSCs, supplementation with BMP-6 and TGF-?
Negative_regulation (reduced) of Gene_expression (expression) of BMP-2 in bone marrow
3) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.24 Pain Relevance 0.07

General Comments

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