INT254348

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.72
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ANGPT1, TEK) extracellular region (ANGPT1, TEK) plasma membrane (ANGPT1, TEK)
cell differentiation (ANGPT1) cell-cell signaling (TEK) cytoplasm (TEK)
ANGPT1 (Homo sapiens)
TEK (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 8 95.12 Very High Very High Very High
rheumatoid arthritis 68 76.36 Quite High
cytokine 14 69.52 Quite High
Arthritis 58 68.44 Quite High
chemokine 118 66.72 Quite High
metalloproteinase 10 39.68 Quite Low
Inflammation 100 37.44 Quite Low
methotrexate 14 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 20 91.80 High High
Apoptosis 2 86.32 High High
Synovitis 8 79.80 Quite High
Rheumatoid Arthritis 68 76.36 Quite High
Arthritis 60 73.68 Quite High
Rheumatic Diseases 32 50.00 Quite Low
INFLAMMATION 100 37.44 Quite Low
Increased Venous Pressure Under Development 74 5.00 Very Low Very Low Very Low
Adhesions 64 5.00 Very Low Very Low Very Low
Disease 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both Ang1 and Ang2 interact with the Tie2 endothelial tyrosine kinase receptor [16,24].
Ang1 Binding (interact) of Tie2
1) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.87 Pain Relevance 0.22
Ang1-Tie2 interactions result in vessel stabilization.
Ang1 Binding (interactions) of Tie2
2) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.85 Pain Relevance 0.26

General Comments

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