INT254352

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CXCR4) signal transducer activity (CXCR4) extracellular space (CXCL12)
signal transduction (CXCL12) extracellular region (CXCL12) cell adhesion (CXCL12)
CXCR4 (Homo sapiens)
CXCL12 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 14 99.98 Very High Very High Very High
Arthritis 58 99.44 Very High Very High Very High
chemokine 118 97.16 Very High Very High Very High
rheumatoid arthritis 68 95.28 Very High Very High Very High
metalloproteinase 10 70.12 Quite High
antagonist 8 47.76 Quite Low
Multiple sclerosis 2 22.92 Low Low
psoriasis 2 20.76 Low Low
Inflammation 100 16.12 Low Low
methotrexate 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 60 99.44 Very High Very High Very High
Rheumatoid Arthritis 68 95.28 Very High Very High Very High
Hypoxia 20 93.28 High High
Synovitis 8 87.52 High High
Rheumatic Diseases 32 55.56 Quite High
Disease 38 33.20 Quite Low
Crohn's Disease 4 26.40 Quite Low
Apoptosis 2 24.32 Low Low
Demyelinating Disease 2 22.92 Low Low
Psoriasis 2 20.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In arthritis, proinflammatory cytokines stimulate the production of SDF-1/CXCL12 and thus tissue vasculogenesis by recruiting CXCR4+ EPCs [14,17,29].


CXCR4 Binding (recruiting) of Positive_regulation (stimulate) of Gene_expression (production) of SDF-1 associated with cytokine and arthritis
1) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.90 Pain Relevance 0.33
In arthritis, proinflammatory cytokines stimulate the production of SDF-1/CXCL12 and thus tissue vasculogenesis by recruiting CXCR4+ EPCs [14,17,29].


CXCR4 Binding (recruiting) of Positive_regulation (stimulate) of Gene_expression (production) of CXCL12 associated with cytokine and arthritis
2) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.90 Pain Relevance 0.33

General Comments

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