INT254360

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.36
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (EPAS1, HIF1A) signal transduction (EPAS1, HIF1A) nucleus (EPAS1, HIF1A)
transcription factor binding (EPAS1, HIF1A) cytoplasm (EPAS1, HIF1A) signal transducer activity (EPAS1, HIF1A)
EPAS1 (Homo sapiens)
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 69 84.84 Quite High
cytokine 16 78.00 Quite High
Arthritis 58 76.92 Quite High
chemokine 123 75.20 Quite High
antagonist 9 73.20 Quite High
metalloproteinase 11 48.16 Quite Low
Inflammation 101 15.52 Low Low
corticosteroid 15 5.00 Very Low Very Low Very Low
methotrexate 14 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 21 100.00 Very High Very High Very High
Follicular Lymphoma 22 97.36 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 97.08 Very High Very High Very High
Synovitis 8 88.28 High High
Rheumatoid Arthritis 71 84.84 Quite High
Lymphatic System Cancer 122 82.92 Quite High
Arthritis 60 76.92 Quite High
Cancer 49 68.72 Quite High
Solid Tumor 1 68.32 Quite High
T-cell Lymphoma 21 65.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HIF1alpha andHIF2alpha were linked with VEGF expression, but no association between HIF1alpha and HIF2alpha was noted.
HIF2alpha Binding (association) of HIF1alpha
1) Confidence 0.39 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.53 Pain Relevance 0
Hypoxia acts through the hypoxia-inducible factor heterodimer, HIF-1?
hypoxia-inducible factor Binding (heterodimer) of HIF-1 associated with hypoxia
2) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.91 Pain Relevance 0.23
Hypoxia acts through the hypoxia-inducible factor heterodimer, HIF-1?
hypoxia-inducible factor Binding (heterodimer) of HIF-1 associated with hypoxia
3) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.91 Pain Relevance 0.23

General Comments

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