INT25438

Context Info Confidence 0.48 First Reported 1989 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 6 Total Number 7 Disease Relevance 4.00 Pain Relevance 2.37

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc) extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)

Anatomy Link Frequency plasma 4 pituitary 2 Pomc (Mus musculus)

Pain Link Frequency Relevance Heat Nicotine 2 99.92 electroacupuncture 24 99.74 Dismenorea 3 98.04 Dopamine 1 96.88 Endogenous opioid 3 94.24 narcan 5 91.28 cytokine 5 90.00 Opioid 4 89.76 opioid receptor 1 87.64 Sciatic nerve 1 85.40

Disease Link Frequency Relevance Heat Stress 58 99.98 Nicotine Addiction 3 99.98 Syndrome 9 99.16 Reprotox - General 1 2 98.04 Ocular Hypotension 4 97.92 Pituitary Cancer 2 97.56 Disease 7 96.40 Ocular Hypertension 3 94.32 Targeted Disruption 1 88.00 Wound Healing 1 87.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is suggested that the mechanism for decreased incidence of dysmenorrhea in female cigarette smokers may lie in the possible inhibition of algesic prostaglandins smoking induced stimulation of beta-endorphin, nicotine, or acrolein.

Spec (possible) Positive_regulation (induced) of Spec (possible) Positive_regulation (stimulation) of beta-endorphin associated with nicotine addiction, nicotine and dismenorea

1) Confidence 0.48 Published 1989 Journal Med. Hypotheses Section Abstract Doc Link 2523509 Disease Relevance 0.45 Pain Relevance 0.26

CONCLUSION: Morbidly obese patients have an increased glucose-stimulated response of beta-endorphin, insulin, and glucose which is partially corrected with weight loss following vertical banded gastroplasty.

Positive_regulation (increased) of Positive_regulation (response) of beta-endorphin

2) Confidence 0.29 Published 1998 Journal J. Surg. Res. Section Body Doc Link 9878302 Disease Relevance 0.11 Pain Relevance 0

In addition, EA stimulation induced an 8-fold increase of endorphin levels in aqueous humor.

Positive_regulation (induced) of Positive_regulation (increase) of endorphin associated with electroacupuncture

3) Confidence 0.16 Published 2002 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 12222760 Disease Relevance 0.61 Pain Relevance 0.85

Extending the use of laparoscopy to the performance of bilateral laparoscopic adrenalectomy is a reasonable alternative for the treatment of ACTH-dependent Cushing's syndrome after failure of surgery for a pituitary adenoma (Cushing's disease) or when the source of ACTH production cannot be resected or localized.[38]

Positive_regulation (alternative) of Positive_regulation (treatment) of ACTH in pituitary associated with syndrome, pituitary cancer and disease

4) Confidence 0.12 Published 2005 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC3004118 Disease Relevance 1.50 Pain Relevance 0

Increase in beta-endorphin levels from the adrenal gland enhances the secretion of insulin, there by reducing plasma glucose levels, and is partially involved in this EA stimulation.

Positive_regulation (enhances) of Positive_regulation (Increase) of beta-endorphin in plasma associated with electroacupuncture

5) Confidence 0.12 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15265586 Disease Relevance 0.09 Pain Relevance 0.82

Restraint stress caused a significant increase in plasma ACTH levels in both the D16 and D19 groups (P < 0.001, F1,35 = 30.5), however, the response was significantly smaller at D19 (P < 0.05, F1,35 = 4.6; Fig. 1A).

Positive_regulation (caused) of Positive_regulation (increase) of ACTH in plasma associated with stress

6) Confidence 0.09 Published 2010 Journal Brain Research Section Body Doc Link PMC2994639 Disease Relevance 0.85 Pain Relevance 0

HEM produced greater increases than LPS in epinephrine (16- vs. 4-fold) and norepinephrine (4-fold vs. 60%) levels and similar elevations in beta-endorphin.

Positive_regulation (increases) of Positive_regulation (elevations) of beta-endorphin

7) Confidence 0.02 Published 2000 Journal Life Sci. Section Abstract Doc Link 10670828 Disease Relevance 0.39 Pain Relevance 0.44

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