INT254388

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.52
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MR1) endoplasmic reticulum (MR1) plasma membrane (MR1)
Anatomy Link Frequency
CD86 2
MR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 98.80 Very High Very High Very High
imagery 8 91.36 High High
cINOD 7 82.44 Quite High
withdrawal 1 61.28 Quite High
dexamethasone 7 59.08 Quite High
tolerance 28 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 588 99.84 Very High Very High Very High
Infection 56 97.12 Very High Very High Very High
Congenital Anomalies 35 92.40 High High
Disease 98 92.24 High High
Nephritis 7 85.40 High High
Pneumocystis Carinii Infection 14 83.92 Quite High
INFLAMMATION 7 82.20 Quite High
Candida Infection 7 81.84 Quite High
Targeted Disruption 7 79.92 Quite High
Apoptosis 35 64.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
New MR systems
Negative_regulation (New) of Gene_expression (systems) of MR
1) Confidence 0.32 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0 Pain Relevance 0.08
The functional consequences of decreased MR expression in SLE DCs are unclear, particularly with regards to susceptibility to infection.
Negative_regulation (decreased) of Gene_expression (expression) of MR associated with systemic lupus erythematosus and infection
2) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 1.01 Pain Relevance 0.03
As expected, decreased MR expression correlated with low FD uptake.
Negative_regulation (decreased) of Gene_expression (expression) of MR
3) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.96 Pain Relevance 0
We demonstrated that SLE moDCs exhibit decreased expression of MR compared with control DCs.
Negative_regulation (decreased) of Gene_expression (expression) of MR associated with systemic lupus erythematosus
4) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.96 Pain Relevance 0
Decreased MR expression in combination with the other receptor deficits and immunologic aberrancies seen in SLE, however, could still contribute to the overall increased susceptibility of patients to assorted infections.
Negative_regulation (Decreased) of Gene_expression (expression) of MR associated with systemic lupus erythematosus and infection
5) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 1.31 Pain Relevance 0
To determine whether the DC maturation status could account for the diminished FD uptake and MR expression, the association with expression of the maturation marker CD86 was examined (Figure 3a).
Negative_regulation (diminished) of Gene_expression (expression) of MR in CD86
6) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.66 Pain Relevance 0
downregulates transcription and surface expression of the MR, and elevated levels of this cytokine have been described in SLE [25].
Negative_regulation (downregulates) of Gene_expression (expression) of MR associated with systemic lupus erythematosus and cytokine
7) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.74 Pain Relevance 0.18
As the MR is the major receptor responsible for FD uptake inhibited by mannose, we then assessed MR expression in SLE moDCs and in control moDCs (Figure 2a).
Negative_regulation (assessed) of Gene_expression (expression) of MR associated with systemic lupus erythematosus
8) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.89 Pain Relevance 0

General Comments

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