INT254393

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.08
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FN1, GSN) extracellular region (FN1, GSN) aging (GSN)
protein complex (GSN) cytoplasm (GSN) cytosol (GSN)
Anatomy Link Frequency
joint 1
FN1 (Homo sapiens)
GSN (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 37 95.36 Very High Very High Very High
Inflammation 26 94.48 High High
Inflammatory mediators 3 74.16 Quite High
methotrexate 7 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Leflunomide 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Etanercept 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 37 95.36 Very High Very High Very High
Injury 12 94.76 High High
INFLAMMATION 28 94.48 High High
Adult Respiratory Distress Syndrome 2 58.48 Quite High
Sepsis 3 56.88 Quite High
Disease 4 55.96 Quite High
Arthritis 3 53.48 Quite High
Alzheimer's Dementia 2 5.00 Very Low Very Low Very Low
Burns 2 5.00 Very Low Very Low Very Low
Pancreatitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to its high affinity for actin, a prime candidate for its localization at an inflamed site containing damaged cells, pGSN binds to fibronectin [37] and fibrin [38,39], which are present at higher-than-normal concentrations in the inflamed joint space during RA [40-42].
fibronectin Binding (binds) of pGSN in joint associated with rheumatoid arthritis
1) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 1.08 Pain Relevance 0.34

General Comments

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