INT254397

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.56
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSN) extracellular space (GSN) vesicle-mediated transport (GSN)
aging (GSN) extracellular region (GSN) protein complex (GSN)
Anatomy Link Frequency
blood 4
plasma 2
GSN (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 177 100.00 Very High Very High Very High
Inflammation 38 100.00 Very High Very High Very High
rheumatoid arthritis 52 89.12 High High
Abeta 3 66.76 Quite High
imagery 3 60.72 Quite High
methotrexate 7 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
intrathecal 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 180 100.00 Very High Very High Very High
INFLAMMATION 40 100.00 Very High Very High Very High
Injury 18 100.00 Very High Very High Very High
Sepsis 9 98.40 Very High Very High Very High
Burns 2 98.00 Very High Very High Very High
Neurodegenerative Disease 6 96.28 Very High Very High Very High
Apoptosis 1 90.12 High High
Rheumatoid Arthritis 52 89.12 High High
Disease 43 76.96 Quite High
Adult Respiratory Distress Syndrome 8 21.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease of GSN concentration in blood and CSF of MS subjects indicates the involvement of this protein in the process of neurodegenerative disease development.
Negative_regulation (decrease) of Gene_expression (concentration) of GSN in blood associated with multiple sclerosis and neurodegenerative disease
1) Confidence 0.41 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 1.25 Pain Relevance 0.43
Additionally, an analysis using Pearson's test indicated a weak correlation between gelsolin levels in CSF and its level in blood.
Negative_regulation (correlation) of Gene_expression (levels) of gelsolin in blood
2) Confidence 0.41 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.63 Pain Relevance 0.29
Here we report that average gelsolin concentrations in CSF collected from patients diagnosed with MS was lower (2.9 ± 1.8 versus 4.1 ± 1.7 ?
Negative_regulation (lower) of Gene_expression (concentrations) of gelsolin associated with multiple sclerosis
3) Confidence 0.36 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.78 Pain Relevance 0.35
Levels of plasma gelsolin decrease during acute injury and inflammation, and administration of recombinant plasma gelsolin to animals improves outcomes following sepsis or burn injuries.
Negative_regulation (decrease) of Gene_expression (Levels) of plasma gelsolin in plasma associated with inflammation, burns, injury and sepsis
4) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2592804 Disease Relevance 0.90 Pain Relevance 0.21

General Comments

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