INT2544

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Context Info
Confidence 0.81
First Reported 1979
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 30.55
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
parathyroid 22
parathyroid gland 5
radius 1
arm 1
pituitary 1
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 100.00 Very High Very High Very High
agonist 9 98.68 Very High Very High Very High
Thoracotomy 12 96.72 Very High Very High Very High
opiate 1 95.24 Very High Very High Very High
gABA 1 91.36 High High
Glutamate 14 91.12 High High
Pain 74 90.24 High High
antagonist 11 89.12 High High
headache 13 87.64 High High
abdominal pain 2 87.24 High High
Disease Link Frequency Relevance Heat
Cancer 96 99.98 Very High Very High Very High
Hypoparathyroidism 5 99.84 Very High Very High Very High
Hyperplasia 23 99.80 Very High Very High Very High
Hypercalcemia 298 99.66 Very High Very High Very High
Disease 86 99.52 Very High Very High Very High
Immunization 16 99.52 Very High Very High Very High
Adenoma 7 99.46 Very High Very High Very High
Hypocalcemia 77 99.44 Very High Very High Very High
Metastasis 114 99.16 Very High Very High Very High
Chronic Renal Failure 33 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Idiopathic hypoparathyroidism is an uncommon disease caused by insufficient secretion of parathyroid hormone.
Localization (secretion) of parathyroid hormone in parathyroid associated with hypoparathyroidism and disease
1) Confidence 0.81 Published 2009 Journal J Clin Rheumatol Section Abstract Doc Link 20009974 Disease Relevance 0.67 Pain Relevance 0.06
Therefore, it is concluded that the changes of PTH secretion are mainly due to mechanisms both of the impaired immune defense of HIV-infected females and the additional effect of opiates.
Localization (secretion) of PTH associated with acquired immune deficiency syndrome or hiv infection and opiate
2) Confidence 0.80 Published 1997 Journal Eur. J. Med. Res. Section Abstract Doc Link 9262487 Disease Relevance 0.86 Pain Relevance 0.10
Magnesium affects the function of the parathyroid glands [14] where it acts as an agonist at the calcium-sensing receptors and, like calcium, can decrease parathyroid hormone (PTH) secretion [15].
Localization (secretion) of parathyroid hormone in parathyroid associated with agonist
3) Confidence 0.80 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2908636 Disease Relevance 0.90 Pain Relevance 0.05
Magnesium affects the function of the parathyroid glands [14] where it acts as an agonist at the calcium-sensing receptors and, like calcium, can decrease parathyroid hormone (PTH) secretion [15].
Localization (secretion) of PTH in parathyroid associated with agonist
4) Confidence 0.80 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2908636 Disease Relevance 0.90 Pain Relevance 0.05
In contrast, radiofrequency ablation (RFA) of the lesion, although complicated by an episode of severe pleuritis, was very successful in achieving biochemical remission, with serum PTH concentrations decreasing from 265 pmol/l to <1 pmol/l (Fig. 2), suggesting that the metastasis targeted with RFA was the only source of PTH secretion.
Localization (secretion) of PTH associated with pleurisy and metastasis
5) Confidence 0.80 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.96 Pain Relevance 0.04
The very high operative risks associated with a third thoracotomy, the patient’s poor lung function and current metabolic status despite regular dialysis, preclude the option of further surgery to remove the identified source of PTH secretion.
Localization (secretion) of PTH in lung associated with thoracotomy
6) Confidence 0.80 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.81 Pain Relevance 0.07
Cinacalcet is a calcimimetic, which reduces parathyroid hormone secretion by binding to the calcium-sensing receptor on parathyroid cells, increasing the sensitivity of these cells to extracellular calcium concentrations [15, 30, 31].
Localization (secretion) of parathyroid hormone in parathyroid
7) Confidence 0.80 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 1.09 Pain Relevance 0
In parathyroid carcinoma, the main goal of treatment is control of hyperparathyroidism by eradicating the source of PTH secretion [7, 16].
Localization (secretion) of PTH in parathyroid associated with parathyroid cancer and hypercalcemia
8) Confidence 0.80 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.96 Pain Relevance 0
Secondary hyperparathyroidism, i.e. increased parathyroid hormone (PTH) secretion and parathyroid gland hyperplasia, develops early in the course of chronic renal insufficiency.
Localization (secretion) of PTH in parathyroid gland associated with hypercalcemia, chronic renal insufficiency and hyperplasia
9) Confidence 0.80 Published 2004 Journal Acta Med Croatica Section Abstract Doc Link 15125393 Disease Relevance 1.51 Pain Relevance 0
Secondary hyperparathyroidism, i.e. increased parathyroid hormone (PTH) secretion and parathyroid gland hyperplasia, develops early in the course of chronic renal insufficiency.
Localization (secretion) of parathyroid hormone in parathyroid gland associated with hypercalcemia, chronic renal insufficiency and hyperplasia
10) Confidence 0.80 Published 2004 Journal Acta Med Croatica Section Abstract Doc Link 15125393 Disease Relevance 1.52 Pain Relevance 0
Primary hyperparathyroidism is a rather frequent pathology characterised by hypersecretion of parathormone (PTH) which is caused by adenomas in 85% of all cases.
Localization (hypersecretion) of PTH associated with adenoma and hypercalcemia
11) Confidence 0.80 Published 2000 Journal Minerva Med. Section Abstract Doc Link 11084846 Disease Relevance 1.26 Pain Relevance 0.09
CONCLUSIONS: The short-term administration of nifedipine results in increased release of parathyroid hormone; however, long-term administration has no significant effect on the concentrations of calciotropic hormones.


Localization (release) of parathyroid hormone in parathyroid
12) Confidence 0.78 Published 1995 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 7889637 Disease Relevance 0.22 Pain Relevance 0
Studies of peripheral and tumor venous blood showed no excess or ectopic parathyroid hormone secretion, but the tumor contained and secreted calcitonin.
Localization (secretion) of parathyroid hormone in parathyroid associated with cancer
13) Confidence 0.78 Published 1979 Journal Ann. Intern. Med. Section Abstract Doc Link 464464 Disease Relevance 1.33 Pain Relevance 0.17
Our patient was affected by severe osteoporosis and THPT, a type of hyperparathyroidism secondary to chronic renal failure not adequately compensated by therapy, in which PTH secretion is independent of the calcium serum concentration and autonomous parathyroid function has developed.
Localization (secretion) of PTH in parathyroid associated with chronic renal failure, hypercalcemia and osteoporosis
14) Confidence 0.76 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656985 Disease Relevance 1.48 Pain Relevance 0.16
Sufficient levels of vitamin D, assessed by measuring 25-hydroxyvitamin D (25(OH)D) concentrations, can be defined as the 25(OH)D concentration that either prevents an increase in parathyroid hormone (PTH), a serum calcium regulator suppressed by 25(OH)D, or optimizes calcium absorption [1].
Localization (increase) of PTH in parathyroid
15) Confidence 0.75 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3017021 Disease Relevance 0.17 Pain Relevance 0.08
Sufficient levels of vitamin D, assessed by measuring 25-hydroxyvitamin D (25(OH)D) concentrations, can be defined as the 25(OH)D concentration that either prevents an increase in parathyroid hormone (PTH), a serum calcium regulator suppressed by 25(OH)D, or optimizes calcium absorption [1].
Localization (increase) of parathyroid hormone in parathyroid
16) Confidence 0.75 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3017021 Disease Relevance 0.17 Pain Relevance 0.08
The authors describes a case of tertiary hyperparathyroidism (HPTH) in a uremic patient on intermittent dialysis treatment: the term refers to an adenoma with ensuing uncontrolled parathormone (PTH) secretion rate arising on the ground of hyperstimulated hypertrophied parathyroid glands.
Localization (secretion) of PTH in parathyroid glands associated with adenoma, hypercalcemia and uremia
17) Confidence 0.75 Published 1993 Journal Minerva Med. Section Abstract Doc Link 8414136 Disease Relevance 1.08 Pain Relevance 0.09
1.76 mmol/L (5.5 mg/dL) after phosphate binder washout, an intact parathyroid hormone (iPTH) measurement of ?
Localization (measurement) of parathyroid hormone in parathyroid
18) Confidence 0.73 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2781155 Disease Relevance 0.33 Pain Relevance 0
Hypocalcemia, phosphate retention and deficiency of calcitriol stimulate PTH synthesis and secretion and parathyroid cell proliferation, i.e. hyperplasia.
Localization (secretion) of PTH in parathyroid associated with hypocalcemia and hyperplasia
19) Confidence 0.70 Published 2004 Journal Acta Med Croatica Section Abstract Doc Link 15125393 Disease Relevance 1.83 Pain Relevance 0.06
Primary hyperparathyroidism is a rather frequent pathology characterised by hypersecretion of parathormone (PTH) which is caused by adenomas in 85% of all cases.
Localization (hypersecretion) of parathormone associated with adenoma and hypercalcemia
20) Confidence 0.69 Published 2000 Journal Minerva Med. Section Abstract Doc Link 11084846 Disease Relevance 1.26 Pain Relevance 0.09

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