INT254401

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.00
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSN) extracellular space (GSN) vesicle-mediated transport (GSN)
aging (GSN) extracellular region (GSN) protein complex (GSN)
Anatomy Link Frequency
cerebrospinal fluid 1
cleavage 1
extracellular matrix 1
GSN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 64 99.68 Very High Very High Very High
Multiple sclerosis 59 99.32 Very High Very High Very High
rheumatoid arthritis 79 93.52 High High
Inflammatory mediators 6 71.16 Quite High
intrathecal 1 47.32 Quite Low
cytokine 9 37.92 Quite Low
Abeta 1 37.44 Quite Low
Osteoarthritis 27 5.00 Very Low Very Low Very Low
methotrexate 14 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 69 99.68 Very High Very High Very High
Demyelinating Disease 60 99.32 Very High Very High Very High
Disease 25 99.12 Very High Very High Very High
Stress 9 98.48 Very High Very High Very High
Rheumatoid Arthritis 80 93.52 High High
Adhesions 1 81.84 Quite High
Injury 26 38.20 Quite Low
Shock 1 27.68 Quite Low
Osteoarthritis 27 5.00 Very Low Very Low Very Low
Sepsis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP-induced pGSN cleavage would most likely be interpreted as a decrease in pGSN concentration in our functional assay since the nucleating activity of pGSN cut in half is weaker than for the full-length protein [47-49].
Positive_regulation (induced) of pGSN in cleavage
1) Confidence 0.38 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.43 Pain Relevance 0.21
Furthermore, MMPs, considered the major enzymes responsible for the extracellular matrix degradation, cleave pGSN in vitro [33,35] and are elevated during inflammation.
Positive_regulation (elevated) of pGSN in extracellular matrix associated with inflammation
2) Confidence 0.38 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.34 Pain Relevance 0.17
Other pharmacological effects of GS involve the modulation of cellular organization processes (increase of gelsolin and decrease of actin) and redox and stress responses (decrease of mitochondrial superoxide dismutase).


Positive_regulation (increase) of gelsolin associated with stress
3) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.32 Pain Relevance 0
Interestingly, in one recent study, up-regulation of gelsolin and DBP in CSF was reported for a pediatric MS group (n = 12) [35] suggesting that in the course of MS development, cerebrospinal fluid GSN and DBP concentrations may indeed increase in some stage of the disease.
Positive_regulation (increase) of GSN in cerebrospinal fluid associated with multiple sclerosis and disease
4) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.91 Pain Relevance 0.41

General Comments

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