INT254402

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.73
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSN) extracellular space (GSN) vesicle-mediated transport (GSN)
aging (GSN) extracellular region (GSN) protein complex (GSN)
Anatomy Link Frequency
blood 1
plasma 1
GSN (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 177 98.72 Very High Very High Very High
Inflammation 38 88.40 High High
rheumatoid arthritis 52 75.84 Quite High
intrathecal 3 61.40 Quite High
cytokine 3 52.00 Quite High
Abeta 3 6.88 Low Low
methotrexate 7 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 180 98.72 Very High Very High Very High
INFLAMMATION 40 88.40 High High
Injury 18 85.52 High High
Adult Respiratory Distress Syndrome 8 83.44 Quite High
Sepsis 9 80.48 Quite High
Myocardial Infarction 3 79.84 Quite High
Hepatitis 3 78.00 Quite High
Anaerobic Bacterial Infections 4 77.12 Quite High
Rheumatoid Arthritis 52 75.84 Quite High
Lumbar Puncture Related Headaches 6 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies revealed a secreted gelsolin isoform in the blood plasma [2,3].
Localization (secreted) of gelsolin in plasma
1) Confidence 0.78 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.87 Pain Relevance 0.13
Immunoblotting of gelsolin in blood and CSF
Localization (Immunoblotting) of gelsolin in blood
2) Confidence 0.72 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.57 Pain Relevance 0.20
The QAlb values indicate lack of CSF-barrier dysfunction in MS subjects included in our study, and it is very likely that the depletion of GSN and DBP from CSF that occurs as these proteins bind actin cannot be compensated for by an increased production or transport of gelsolin.
Localization (depletion) of GSN associated with multiple sclerosis
3) Confidence 0.72 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.49 Pain Relevance 0.24
Differentially processed mRNA transcripts present in various cell types [2,3] and originating from a gene on chromosome 9 program the synthesis of intracellular gelsolin (cGSN) and of its secreted counterpart.
Localization (secreted) of cGSN
4) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.81 Pain Relevance 0.07

General Comments

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