INT254426

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.28
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Lrp5) endoplasmic reticulum (Lrp5) plasma membrane (Lrp5)
Anatomy Link Frequency
osteoclast 1
Lrp5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 14 63.84 Quite High
antagonist 4 50.00 Quite Low
agonist 3 22.12 Low Low
Inflammatory response 5 17.92 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
Serotonin 7 5.00 Very Low Very Low Very Low
diabetic neuropathy 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 309 98.68 Very High Very High Very High
Stress Fractures 106 98.52 Very High Very High Very High
Syndrome 9 85.00 Quite High
Renal Disease 10 82.48 Quite High
Apoptosis 8 81.64 Quite High
Chronic Renal Failure 2 81.28 Quite High
Osteoporosis 60 78.80 Quite High
Obesity 54 77.84 Quite High
Alzheimer's Dementia 2 74.56 Quite High
Disease 38 72.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genotyping of 15 SNPs in the VDR, CTR, IL-6, COL1A1, COL1A2, and LRP5 genes
Gene_expression (genes) of LRP5
1) Confidence 0.67 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.21 Pain Relevance 0
Seven haplotypes were detected in the LRP5 gene.
Gene_expression (detected) of LRP5
2) Confidence 0.67 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.58 Pain Relevance 0
In contrast, neither humans nor mice lacking LRP5 display any apparent alteration in osteoclast differentiation or function.
Neg (lacking) Gene_expression (lacking) of LRP5 in osteoclast
3) Confidence 0.66 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.16 Pain Relevance 0
Carriers of LRP5 variants have BMD 0.17 to 0.57 standard deviations away from the population mean [45,46].
Gene_expression (variants) of LRP5
4) Confidence 0.66 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.46 Pain Relevance 0
Lrp6 (low-density lipoprotein receptor-related protein 6) encodes a transmembrane protein that has 71% identity with, and is structurally similar to, a product of Lrp5 (low-density lipoprotein receptor-related protein 5), a proposed candidate gene for T1D [78].
Gene_expression (product) of Lrp5 associated with diabetes mellitus
5) Confidence 0.54 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.93 Pain Relevance 0.03
Lrp6 (low-density lipoprotein receptor-related protein 6) encodes a transmembrane protein that has 71% identity with, and is structurally similar to, a product of Lrp5 (low-density lipoprotein receptor-related protein 5), a proposed candidate gene for T1D [78].
Gene_expression (product) of receptor-related protein 5 associated with diabetes mellitus
6) Confidence 0.54 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.94 Pain Relevance 0.03

General Comments

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