INT254427

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 5.43
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Lrp5) endoplasmic reticulum (Lrp5) plasma membrane (Lrp5)
Anatomy Link Frequency
body 2
neck 1
osteocyte 1
Lrp5 (Mus musculus)
Lrp5 - G171V (1)
Pain Link Frequency Relevance Heat
Serotonin 49 79.16 Quite High
antagonist 22 70.28 Quite High
midbrain 7 64.96 Quite High
agonist 7 28.56 Quite Low
Pain 10 12.40 Low Low
cINOD 14 5.00 Very Low Very Low Very Low
adenocard 7 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Osteoarthritis 7 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 81 99.74 Very High Very High Very High
Stress Fractures 159 98.36 Very High Very High Very High
Body Weight 27 97.82 Very High Very High Very High
Congenital Anomalies 28 95.28 Very High Very High Very High
Syndrome 28 93.84 High High
Hypophosphatemia 3 93.12 High High
Hypocalcemia 3 92.40 High High
Retina Disease 7 91.24 High High
Osteoporosis 129 90.56 High High
Targeted Disruption 8 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Body weight is an important predictor of BMD [48], and BMI and obesity have been shown in a family-based analysis to be associated with LRP5 polymorphisms [49], underlining the role of LRP5 also in weight regulation.
LRP5 Binding (associated) of in Body associated with body weight and obesity
1) Confidence 0.48 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.96 Pain Relevance 0
However, subsequent work demonstrated that it also bound Lrp5 and Lrp6 and could prevent their interaction with Wnts [17–19].
Lrp5 Binding (bound) of
2) Confidence 0.47 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.40 Pain Relevance 0.04
In addition, some reports (but not all [71]) found that the version of the LRP5 protein found in HBM families (G171V) could not bind to or be inhibited by DKK1 [83, 84].
LRP5 protein Neg (not) Binding (bind) of
3) Confidence 0.47 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.27 Pain Relevance 0.03
The association of LRP5 with bone density is apparent even in childhood, indicating a likely effect on bone accrual [37,44].
LRP5 Binding (association) of
4) Confidence 0.47 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.48 Pain Relevance 0
The present study indicates that the association of the LRP5 haplotype and LRP5-VDR interaction with stress fractures is mediated by low body weight and BMI, but more research is needed before any definitive conclusions can be drawn from these findings.
LRP5 Binding (association) of in body associated with body weight, obesity and stress fractures
5) Confidence 0.37 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.97 Pain Relevance 0
These mutations were either in the gene encoding the low density lipoprotein receptor-related protein-5 (LRP5) or in a gene (SOST) encoding a protein (Sclerostin) that potentially binds and regulates the function of LRP5 and its family members LRP4 and LRP6.
LRP5 Binding (function) of
6) Confidence 0.37 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.18 Pain Relevance 0.04
-catenin signaling via binding directly to LRP5 and LRP6 and blocked the ability of Wnt ligands to interact with LRP5 and LRP6 [80–82].
LRP5 Binding (interact) of
7) Confidence 0.37 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.25 Pain Relevance 0.03
Wnts initiate signaling by binding to a member of the Frizzled family of seven transmembrane receptors and either LRP5 or LRP6 [8–10] (Figure 1), leading to downregulation of glycogen synthase kinase-3 (GSK-3) activity.
LRP5 Binding (binding) of
8) Confidence 0.37 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0 Pain Relevance 0.13
The most important physical variable was weight, because reduced weight and BMI mediate the association of the LRP5 haplotype and the LRP5-VDR interaction with femoral neck stress fractures.
LRP5 Binding (association) of in neck associated with obesity and stress fractures
9) Confidence 0.35 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.85 Pain Relevance 0
Linkage of LRP5 Mutations to Conditions with Altered Bone Mass
LRP5 Binding (Linkage) of
10) Confidence 0.35 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.37 Pain Relevance 0
The LRP5-G171V protein can no longer be bound by several proteins (such as Dkk1, Sost, and MESD) that may normally regulate its activity.
LRP5 (G171V) Neg (no) Binding (bound) of
11) Confidence 0.35 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.56 Pain Relevance 0
Sclerostin after secretion by osteocytes travels through osteocyte canaliculi to the bone surface where it binds to coreceptors LRP5 and LRP6 thus preventing colocalization with frizzled protein and Wnt signaling, and thereby reducing osteoblastogenesis and bone formation [3].
LRP5 Binding (binds) of in osteocyte
12) Confidence 0.17 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.13 Pain Relevance 0

General Comments

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