INT254428

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.52
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure development (Lrp4) plasma membrane (Lrp4)
Anatomy Link Frequency
Tid1 1
femur 1
Lrp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 14 80.12 Quite High
Pain 2 65.84 Quite High
antagonist 7 50.00 Quite Low
anesthesia 2 35.28 Quite Low
agonist 2 16.00 Low Low
cINOD 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Myasthenic Syndromes 44 98.96 Very High Very High Very High
Congenital Anomalies 12 97.36 Very High Very High Very High
Osteoporosis 64 92.80 High High
Disease 27 91.16 High High
Bone Cancer 13 90.96 High High
Syndrome 16 68.04 Quite High
Pain 2 65.84 Quite High
Retina Disease 2 65.44 Quite High
Cancer 8 56.96 Quite High
Fracture Healing 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mutations were either in the gene encoding the low density lipoprotein receptor-related protein-5 (LRP5) or in a gene (SOST) encoding a protein (Sclerostin) that potentially binds and regulates the function of LRP5 and its family members LRP4 and LRP6.
LRP4 Binding (binds) of
1) Confidence 0.44 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.18 Pain Relevance 0.04
In addition, it has recently been shown that LRP4, which is expressed in bone and cultured osteoblasts, binds Dkk1 and sclerostin in vitro and that Lrp4-deficient mice revealed shortened total femur length, reduced cortical femoral perimeter, reduced total femur bone mineral content (BMC), and bone mineral density (BMD) [58].
LRP4 Binding (binds) of in femur
2) Confidence 0.33 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.64 Pain Relevance 0.07
When tested in the overall BMD cohort, these regions did achieve moderate level association with BMD (2p16, P = 8 × 10-7; LRP4, P = 3 × 10-4).
LRP4 Binding (association) of
3) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.14 Pain Relevance 0
We found that the interaction of the patient's MuSK mutants with the co-receptor of agrin Lrp4 was not affected.
Lrp4 Binding (interaction) of
4) Confidence 0.16 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.28 Pain Relevance 0
Our findings demonstrate that missense mutations in MUSK can result in a severe form of CMS and indicate that the inability of MuSK mutants to interact with Dok-7, but not with Lrp4 or Tid1, is a major determinant of the pathogenesis of the CMS caused by MUSK mutations.



Lrp4 Binding (interact) of in Tid1 associated with congenital myasthenic syndromes
5) Confidence 0.15 Published 2010 Journal Human Molecular Genetics Section Abstract Doc Link PMC2876883 Disease Relevance 0.27 Pain Relevance 0

General Comments

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