INT254429

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.95
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Lrp5) endoplasmic reticulum (Lrp5) plasma membrane (Lrp5)
Anatomy Link Frequency
duodenum 1
Lrp5 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 14 98.08 Very High Very High Very High
antagonist 7 50.00 Quite Low
cINOD 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 11 99.04 Very High Very High Very High
Retina Disease 2 99.00 Very High Very High Very High
Osteoporosis 67 95.64 Very High Very High Very High
Disease 27 94.64 High High
Osteopetrosis 1 92.40 High High
Stress Fractures 53 89.48 High High
Obesity 27 83.44 Quite High
Bone Cancer 14 79.44 Quite High
Nicotine Addiction 3 69.28 Quite High
Body Weight 9 51.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Shortly after loss of LRP5 function was linked to OPPG, two groups independently reported that families with extremely high bone mass (HBM) carried a specific point mutation (G171V) in LRP5 [49, 50].
Negative_regulation (loss) of LRP5 associated with syndrome
1) Confidence 0.57 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.59 Pain Relevance 0
One of the more interesting areas of research has centered around the observation by Yadav and colleagues that loss of LRP5 leads to low bone mass due to dysregulation of serotonin synthesis from the enterochromaffin cells of the duodenum [1].
Negative_regulation (loss) of LRP5 in duodenum associated with serotonin
2) Confidence 0.42 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.16 Pain Relevance 0.18
Of particular interest are treatments targeting sclerostin (encoded by the gene SOST), which is thought to inhibit LRP5.
Negative_regulation (inhibit) of LRP5
3) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.64 Pain Relevance 0
A linkage disequilibrium plot for the VDR, COL1A1, COL1A2, and LRP5 SNPs is presented in Figures 1A-D.
Negative_regulation (presented) of LRP5
4) Confidence 0.19 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.56 Pain Relevance 0

General Comments

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