INT254433

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.51
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sost) mitochondrion (Lrp5) extracellular region (Sost)
Golgi apparatus (Sost) endoplasmic reticulum (Lrp5) plasma membrane (Lrp5)
Lrp5 (Mus musculus)
Sost (Mus musculus)
Lrp5 - G171V (1)
Pain Link Frequency Relevance Heat
antagonist 7 59.92 Quite High
agonist 2 18.20 Low Low
Pain 2 15.60 Low Low
Serotonin 14 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteopetrosis 1 97.72 Very High Very High Very High
Disease 25 96.36 Very High Very High Very High
Syndrome 10 95.44 Very High Very High Very High
Osteoporosis 64 91.60 High High
Retina Disease 2 91.24 High High
Congenital Anomalies 8 84.92 Quite High
Conductive Hearing Loss 2 48.76 Quite Low
Facial Paralysis 2 47.64 Quite Low
Syndactyly 4 40.36 Quite Low
Pain 2 15.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the skeletal overgrowth seen in patients carrying the G171V mutation in LRP5, Sost is unable to interact with the mutated version of LRP5 [70, 71].
LRP5 Neg (unable) Binding (interact) of Sost
1) Confidence 0.39 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.24 Pain Relevance 0.03
The LRP5-G171V protein can no longer be bound by several proteins (such as Dkk1, Sost, and MESD) that may normally regulate its activity.
LRP5 (G171V) Binding (bound) of Sost
2) Confidence 0.30 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.57 Pain Relevance 0
Common polymorphisms of SOST have also been demonstrated to be associated with general population variation in BMD [45,50], although this has been less well studied than LRP5.
LRP5 Binding (associated) of SOST
3) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.70 Pain Relevance 0

General Comments

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