INT254434

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Lrp5, Best1) transport (Best1) mitochondrion (Lrp5)
endoplasmic reticulum (Lrp5)
Anatomy Link Frequency
hip 1
Lrp5 (Mus musculus)
Best1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Cancer 4 100.00 Very High Very High Very High
Obesity 54 95.44 Very High Very High Very High
Body Weight 18 95.12 Very High Very High Very High
Stress Fractures 106 93.88 High High
Osteoporosis 94 88.52 High High
Hypophosphatemia 2 83.80 Quite High
Hypocalcemia 2 83.08 Quite High
Targeted Disruption 6 80.64 Quite High
Osteoporotic Fractures 14 79.76 Quite High
Syndrome 10 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As discussed below, two studies [46,47] recently demonstrated association of LRP5 with BMD, achieving genome-wide significance (P < 10-7).
LRP5 Binding (association) of BMD
1) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.40 Pain Relevance 0
Our group recently demonstrated this with a proof-of-principle study [45], which easily confirmed the known association of LRP5 with BMD in a cohort of just 320 postmenopausal women selected for extreme BMD at the hip.
LRP5 Binding (association) of BMD in hip
2) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592817 Disease Relevance 0.23 Pain Relevance 0
The function of LRP5 in bone development, however, is indisputable [41]; mutations in LRP5 cause various bone disorders [20,42] and polymorphisms are associated with BMD and bone mineral content in general [43], but also with reduced BMD and fractures [44].
LRP5 Binding (associated) of BMD associated with bone cancer
3) Confidence 0.04 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.98 Pain Relevance 0
The function of LRP5 in bone development, however, is indisputable [41]; mutations in LRP5 cause various bone disorders [20,42] and polymorphisms are associated with BMD and bone mineral content in general [43], but also with reduced BMD and fractures [44].
LRP5 Binding (associated) of BMD associated with bone cancer
4) Confidence 0.04 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.92 Pain Relevance 0

General Comments

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