INT25445

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Context Info
Confidence 0.41
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 15
Disease Relevance 12.75
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
molecular_function (Plat) cytoplasm (Plat)
Anatomy Link Frequency
middle cerebral artery 1
chest 1
endothelium 1
Plat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 4 98.52 Very High Very High Very High
anesthesia 45 96.84 Very High Very High Very High
cva 23 93.80 High High
Inflammatory response 10 92.44 High High
IPN 5 91.12 High High
ischemia 89 88.64 High High
corticosteroid 9 86.20 High High
aspirin 10 84.64 Quite High
Glutamate 10 76.12 Quite High
Inflammation 32 67.12 Quite High
Disease Link Frequency Relevance Heat
Stroke 550 100.00 Very High Very High Very High
Middle Cerebral Artery Infarction 291 99.96 Very High Very High Very High
Myocardial Infarction 8 99.50 Very High Very High Very High
Angina 1 98.52 Very High Very High Very High
Adhesions 22 98.20 Very High Very High Very High
Increased Venous Pressure Under Development 9 97.48 Very High Very High Very High
Thrombosis 7 95.72 Very High Very High Very High
Coagulation Disorder 2 94.20 High High
Cv General 3 Under Development 16 93.80 High High
Death 33 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of the ischemic stroke genes were also regulated by tPA, indicating an interaction between ischemic stroke and tPA.
tPA Binding (interaction) of associated with stroke
1) Confidence 0.41 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.77 Pain Relevance 0.12
Gene expression associated with tPA administration was examined in an ANOVA model including tPA, ischemic stroke, anesthesia, and the interaction between tPA and ischemic stroke. tPA, ischemic stroke, and the interaction between tPA and ischemic stroke were found to affect gene expression.
tPA Binding (associated) of associated with anesthesia and stroke
2) Confidence 0.37 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.20 Pain Relevance 0.12
Additionally, we were only able to investigate a single dosage of tPA at a single time point.
tPA Binding (dosage) of
3) Confidence 0.37 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.63 Pain Relevance 0.16
In rats with permanent-MCAO, treatment with tPA led to differential regulation of 293 gene probes at 24 hours (p ?
tPA Binding (treatment) of associated with middle cerebral artery infarction
4) Confidence 0.37 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.34 Pain Relevance 0
Some genes expressed following administration of tPA interacted with ischemic stroke, with a different gene expression profile for tPA in rats with middle cerebral artery occlusion (MCAO) followed by reperfusion compared to rats with permanent-MCAO.
tPA Binding (interacted) of in middle cerebral artery associated with middle cerebral artery infarction and stroke
5) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.28 Pain Relevance 0.09
An interaction was identified between tPA and ischemic stroke.
tPA Binding (interaction) of associated with stroke
6) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.36 Pain Relevance 0.15
There were 2332 gene probes regulated by ischemic stroke and 983 gene probes regulated by the interaction of ischemic stroke with tPA (p ?
tPA Binding (interaction) of associated with stroke
7) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.32 Pain Relevance 0.15
Despite the interaction between tPA and ischemic stroke, the majority of the genes regulated by tPA can be distinguished from genes regulated by ischemic stroke.


tPA Binding (interaction) of associated with stroke
8) Confidence 0.35 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.25 Pain Relevance 0.08
Indirectly tPA modulates immune cells that interact with endothelium. tPA increases endothelial adhesion molecule expression including ICAM2, P-Selectin, and E-Selectin [20,21].
tPA Binding (interact) of in endothelium associated with adhesions
9) Confidence 0.32 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.58 Pain Relevance 0.03
Other factors included in the plasminogen/plasmin and fibrinolytic system, such as tPA, uPA and PAI-1, can participate in the tissue remodelling of the ECM directly through the binding to specific receptors, and through the transformation of the plasminogen precursor bound to the cell surface to plasmin, which is an active serine protease.
tPA Binding (binding) of
10) Confidence 0.23 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.06 Pain Relevance 0.14
Aside from the porous structure, other factors including the content of the crosslinker, PLGA and t-PA could all be varied to regulate t-PA release from the hydrogel.
t-PA Binding (crosslinker) of
11) Confidence 0.15 Published 2001 Journal J Control Release Section Abstract Doc Link 11451495 Disease Relevance 0 Pain Relevance 0.24
The tissue type plasminogen activator (tPA) binds specifically to fibrin, and there increases its activity several-fold and activates the powerful proteolytic enzyme plasmin only at the site of clotting.
tPA Binding (binds) of associated with coagulation disorder
12) Confidence 0.10 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.09 Pain Relevance 0
tissue plasminogen activator (tPA), which has anticoagulant properties and is used to lyse existing clots, may be a useful therapeutic gene for antithrombotic therapy (Table 1).
tPA Binding (used) of
13) Confidence 0.06 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.58 Pain Relevance 0
Studies showed that administering melatonin in combination with t-PA at the onset (MCAO) or six hours after reperfusion (laser-beam induced occlusion) decreases t-PA induced iNOS expression and hemorrhagic formation as well as restores p-AKT levels.45
t-PA Binding (combination) of associated with middle cerebral artery infarction
14) Confidence 0.03 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695239 Disease Relevance 1.42 Pain Relevance 0.23
Among 11 consecutive patients with acute myocardial infarction undergoing thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) 3.2 +/- 0.7 h after onset of chest pain, and angiography 10.2 +/- 4.5 days later, three young men had normal coronary arteries.
tissue plasminogen activator Binding (therapy) of in chest associated with angina and myocardial infarction
15) Confidence 0.02 Published 1989 Journal Eur. Heart J. Section Abstract Doc Link 2524385 Disease Relevance 0.86 Pain Relevance 0.14

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