INT254460

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 0.48
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Calm2, Ca2) cytosol (Calm2, Ca2) nucleoplasm (Calm2)
lyase activity (Ca2) response to stress (Ca2) extracellular space (Ca2)
Anatomy Link Frequency
pore 1
Calm2 (Rattus norvegicus)
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 110 99.72 Very High Very High Very High
tetrodotoxin 20 5.00 Very Low Very Low Very Low
imagery 16 5.00 Very Low Very Low Very Low
Migraine 14 5.00 Very Low Very Low Very Low
Action potential 12 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
sodium channel 7 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 28 94.76 High High
Syndrome 28 76.60 Quite High
Channelopathies 56 71.60 Quite High
Ganglion Cysts 56 5.00 Very Low Very Low Very Low
Disease 21 5.00 Very Low Very Low Very Low
Congenital Anomalies 14 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 12 5.00 Very Low Very Low Very Low
Infection 12 5.00 Very Low Very Low Very Low
Migraine With Aura 7 5.00 Very Low Very Low Very Low
Headache 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With mild depolarization, the frequency of L-type channel openings would be low enough to allow Ca2+ to dissociate from CaM and/or for Ca2+/CaM to diffuse away from its target between openings.
CaM Binding (dissociate) of Ca2
1) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.03
With mild depolarization, the frequency of L-type channel openings would be low enough to allow Ca2+ to dissociate from CaM and/or for Ca2+/CaM to diffuse away from its target between openings.
CaM Binding (dissociate) of Ca2
2) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.03
When adjacent subunits bind Ca2+/CaM, they reciprocally prolong their activated state through autophosphorylation and CaM trapping, a steeply frequency-dependent process.
CaM Binding (bind) of Ca2
3) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.08
With mild depolarization, the frequency of L-type channel openings would be low enough to allow Ca2+ to dissociate from CaM and/or for Ca2+/CaM to diffuse away from its target between openings.
CaM Binding (dissociate) of Ca2
4) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.03
Much is now known about the positioning of Ca2+-free CaM (apoCaM) on the channel, the binding of Ca2+ to this “pre-associated” CaM, and the initial Ca2+/CaM interaction sites on the channel (Dunlap, 2007).
CaM Binding (binding) of Ca2
5) Confidence 0.02 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.08 Pain Relevance 0
Much is now known about the positioning of Ca2+-free CaM (apoCaM) on the channel, the binding of Ca2+ to this “pre-associated” CaM, and the initial Ca2+/CaM interaction sites on the channel (Dunlap, 2007).
CaM Binding (binding) of Ca2
6) Confidence 0.02 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.07 Pain Relevance 0
Beyond Ca2+ binding to CaM, J(Ca2+) could incorporate either the affinity of an inactivation particle for its pore-blocking binding site (case 1), or the efficacy with which mechanical forces transduce selectivity filter collapse (case 2).
CaM Binding (binding) of Ca2 in pore associated with shock
7) Confidence 0.02 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.09 Pain Relevance 0.11
Much is now known about the positioning of Ca2+-free CaM (apoCaM) on the channel, the binding of Ca2+ to this “pre-associated” CaM, and the initial Ca2+/CaM interaction sites on the channel (Dunlap, 2007).
CaM Binding (binding) of Ca2
8) Confidence 0.02 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.07 Pain Relevance 0
For example, it is known that Ca2+ binds to a constitutively associated calmodulin (CaM), which then interacts with other sites on the channel to induce CDI (Lee et al., 1999, 2003; Peterson et al., 1999; Zühlke et al., 1999; Erickson et al., 2001, 2003; Pitt et al., 2001; Mori et al., 2004; Dick et al., 2008; Tadross et al., 2008).
CaM Binding (associated) of Ca2
9) Confidence 0.02 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.07 Pain Relevance 0
In particular, the behavior of the scheme in Fig. 1 C is shown to correspond well to the detailed CDI scheme in our companion paper (Tadross and Yue, 2010), which allows for inactivation from both closed and open states, and dissects the CDI process into separate events representing Ca2+ binding to CaM, CaM/channel binding, and the final transduction of CDI.
CaM Binding (binding) of Ca2
10) Confidence 0.02 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0
Importantly, the dependence of J(Ca2+) on PO-PEAK arises because only open channels conduct the Ca2+ entry required for Ca2+ binding to CaM; this dependence is not necessarily due to any preferential state dependence of CDI transduction per se.
CaM Binding (binding) of Ca2 associated with addiction
11) Confidence 0.02 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.09 Pain Relevance 0.15

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