INT254484

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.90
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sorbs1) transport (Sorbs1) plasma membrane (Sorbs1)
cytoskeleton (Sorbs1) nucleus (Sorbs1) cytoplasm (Sorbs1)
Anatomy Link Frequency
fat cells 3
ventral 2
muscle 1
Sorbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 6 100.00 Very High Very High Very High
Spinal cord 7 93.56 High High
Central nervous system 26 81.24 Quite High
Inflammation 78 50.00 Quite Low
tolerance 37 5.00 Very Low Very Low Very Low
antagonist 28 5.00 Very Low Very Low Very Low
Inflammatory marker 21 5.00 Very Low Very Low Very Low
potassium channel 16 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumonia 90 100.00 Very High Very High Very High
Obesity 98 98.64 Very High Very High Very High
Chronic Disease 12 80.36 Quite High
Hyperinsulinism 20 61.04 Quite High
Bacterial Pneumonia 3 50.88 Quite High
INFLAMMATION 105 50.00 Quite Low
Sepsis 54 38.04 Quite Low
Congenital Anomalies 18 14.88 Low Low
Nicotine Addiction 9 10.24 Low Low
Diabetes Mellitus 60 9.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Older subjects were more likely to have severe CAP upon presentation, as evidenced by greater proportion of older adults with a Pneumonia Severity Index score ?
Positive_regulation (severe) of Gene_expression (severe) of CAP associated with pneumonia
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973976 Disease Relevance 0.33 Pain Relevance 0
Older subjects were more likely to have severe CAP upon presentation, as evidenced by greater proportion of older adults with a Pneumonia Severity Index score ?
Positive_regulation (have) of Gene_expression (severe) of CAP associated with pneumonia
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973976 Disease Relevance 0.33 Pain Relevance 0
Older subjects were more likely to have severe CAP upon presentation, as evidenced by greater proportion of older adults with a Pneumonia Severity Index score ?
Positive_regulation (have) of Gene_expression (have) of CAP associated with pneumonia
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973976 Disease Relevance 0.33 Pain Relevance 0
Thus, the amplitude and shape of ventral column CAPs from Claudin 11–null mice are similar to controls and differ only by an increase in CAP duration (Fig.
Positive_regulation (increase) of Gene_expression (duration) of CAP in ventral
4) Confidence 0.04 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592840 Disease Relevance 0 Pain Relevance 0.11
Intriguingly, whereas many growth factors trigger the activation of PI3K, AKT, and PKC in many cell types, aspects of the c-Cbl–CAP pathway, including the tyrosine phosphorylation and the expression of CAP, seem to be unique to muscle and fat cells [144].
Positive_regulation (activation) of Gene_expression (expression) of CAP in fat cells associated with kinase c and obesity
5) Confidence 0.04 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.46 Pain Relevance 0.13
Intriguingly, whereas many growth factors trigger the activation of PI3K, AKT, and PKC in many cell types, aspects of the c-Cbl–CAP pathway, including the tyrosine phosphorylation and the expression of CAP, seem to be unique to muscle and fat cells [144].
Positive_regulation (activation) of in muscle Gene_expression (expression) of CAP in fat cells associated with kinase c and obesity
6) Confidence 0.01 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.46 Pain Relevance 0.13

General Comments

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