INT2545

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Context Info
Confidence 0.17
First Reported 1979
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.22
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Cys1) cilium (Cys1) molecular_function (Cys1)
biological_process (Cys1) cytoplasm (Cys1)
Anatomy Link Frequency
myocardium 1
muscle 1
heart 1
Cys1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 98.00 Very High Very High Very High
isoflurane 1 68.28 Quite High
anesthesia 4 67.04 Quite High
Analgesic 1 10.00 Low Low
Pain score 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fasciculation 9 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 7 100.00 Very High Very High Very High
Myalgia 7 99.90 Very High Very High Very High
Injury 4 99.74 Very High Very High Very High
Heart Rate Under Development 1 99.60 Very High Very High Very High
Hypoxia 5 99.22 Very High Very High Very High
Contracture 3 98.20 Very High Very High Very High
Stress 4 98.14 Very High Very High Very High
Pain 3 90.20 High High
Paralysis 1 69.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Present study was undertaken to show whether any correlation of the degree of fasciculation and postsuxamethonium myalgia is present or not and whether diazepam has any role in reducing muscle injury and in turn reducing the levels of serum K+ and CPK.
Negative_regulation (reducing) of CPK in muscle associated with fasciculation, injury and myalgia
1) Confidence 0.17 Published 1996 Journal J Indian Med Assoc Section Abstract Doc Link 8810174 Disease Relevance 0.71 Pain Relevance 0.17
Nevertheless, these pretreatment did not improve postoperative myalgia and decrease serum CPK.
Neg (not) Negative_regulation (decrease) of serum CPK associated with disorders of creatine metabolism and myalgia
2) Confidence 0.09 Published 1990 Journal Ma Zui Xue Za Zhi Section Abstract Doc Link 2277574 Disease Relevance 0.76 Pain Relevance 0.16
Diazepam pretreatment prevented muscle fasciculations, increases in serum potassium (K+) and creatinine phosphokinase (CPK) levels, increased heart rate and arterial pressure, and postoperative myalgia associated with SCh administration.
Negative_regulation (prevented) of CPK in heart associated with heart rate under development, fasciculation and myalgia
3) Confidence 0.06 Published 1979 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 466933 Disease Relevance 0.44 Pain Relevance 0
Experiments on the isolated hearts of rats, subjected to emotional and painful stress have shown it to potentiate the ischaemic and hypoxic damage of the heart, evaluated by the loss of CPK enzyme by the myocardium and the degree of hypoxic contracture.
Negative_regulation (loss) of CPK enzyme in myocardium associated with stress, pain, hypoxia and contracture
4) Confidence 0.05 Published 1982 Journal Kardiologiia Section Abstract Doc Link 7202079 Disease Relevance 1.09 Pain Relevance 0.10
STUDY OBJECTIVE: To determine if pretreatment with either gallamine or mivacurium before succinylcholine in children is associated with reduction in fasciculations; postoperative myalgias; or serum levels of potassium, creatinine phosphokinase (CPK), and myoglobin.
Negative_regulation (reduction) of CPK associated with fasciculation
5) Confidence 0.05 Published 2001 Journal J Clin Anesth Section Abstract Doc Link 11435054 Disease Relevance 0.10 Pain Relevance 0
The decline of serum CPK levels started 1 week after surgery.
Negative_regulation (decline) of serum CPK
6) Confidence 0.03 Published 2007 Journal Journal of neurosurgery. Spine Section Body Doc Link 17330578 Disease Relevance 0.12 Pain Relevance 0

General Comments

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