INT254544

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.85
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
Anatomy Link Frequency
PLB-985 2
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 34 97.36 Very High Very High Very High
ischemia 20 12.88 Low Low
cva 14 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 38 97.36 Very High Very High Very High
Urological Neuroanatomy 18 93.52 High High
Disease 26 77.44 Quite High
Leukemia 8 66.76 Quite High
Chronic Lymphoid Leukemia 1 53.00 Quite High
Targeted Disruption 13 40.00 Quite Low
Cv Unclassified Under Development 18 12.88 Low Low
Lung Injury 8 11.20 Low Low
Stress 20 9.52 Low Low
Cancer 8 8.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
effect of NADPH-oxidase inhibition and, to a lesser extent in less extension,
Regulation (effect) of Gene_expression (inhibition) of NADPH-oxidase
1) Confidence 0.39 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.33 Pain Relevance 0.04
To test whether this parallel change in protein level reflects an interdependence of Hv1 and Nox2 expression, the experiment was repeated in Nox2 deficient (X CGD) PLB-985 cells.
Spec (whether) Regulation (interdependence) of Gene_expression (expression) of Nox2 in PLB-985
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.12 Pain Relevance 0
Apocynin, after metabolic conversion, inhibits the assembly of NADPH-oxidase that is responsible for reactive oxygen species (ROS) production.
Regulation (responsible) of Gene_expression (production) of NADPH-oxidase
3) Confidence 0.24 Published 2008 Journal Mediators of Inflammation Section Abstract Doc Link PMC2593395 Disease Relevance 0.40 Pain Relevance 0.13

General Comments

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