INT254566

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 9.51
Pain Relevance 9.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PAG1) plasma membrane (PAG1) intracellular (PAG1)
Anatomy Link Frequency
neurons 6
output neurons 2
lateral 2
PAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 633 100.00 Very High Very High Very High
Rostral ventromedial medulla 204 100.00 Very High Very High Very High
amygdala 178 100.00 Very High Very High Very High
Periaqueductal grey 86 100.00 Very High Very High Very High
mu opioid receptor 60 100.00 Very High Very High Very High
gABA 20 99.96 Very High Very High Very High
projection neuron 8 98.88 Very High Very High Very High
tolerance 52 98.84 Very High Very High Very High
Morphine 316 98.68 Very High Very High Very High
Pain 107 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 753 100.00 Very High Very High Very High
Stress 313 99.68 Very High Very High Very High
Cold Sores 63 99.24 Very High Very High Very High
Pain 141 98.28 Very High Very High Very High
Anxiety Disorder 121 97.56 Very High Very High Very High
Hyperalgesia 32 96.32 Very High Very High Very High
Nociception 22 87.52 High High
Inflammatory Pain 20 59.28 Quite High
INFLAMMATION 16 43.36 Quite Low
Arthritis 8 36.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mediated by a reduction in MOR signaling efficacy in PAG neurons

[119], an effect

Negative_regulation (reduction) of Gene_expression (neurons) of PAG in neurons associated with mu opioid receptor and central grey
1) Confidence 0.33 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.03 Pain Relevance 2.27
depolarize PAG neurons.
Negative_regulation (depolarize) of Gene_expression (neurons) of PAG in neurons associated with central grey
2) Confidence 0.33 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.31 Pain Relevance 1.81
However, when the analysis was limited to PAG neurons
Negative_regulation (limited) of Gene_expression (neurons) of PAG in neurons associated with central grey
3) Confidence 0.33 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.29 Pain Relevance 1.81
females had significantly more PAG-RVM output neurons across the rostrocaudal
Negative_regulation (more) of Gene_expression (output neurons) of PAG-RVM in output neurons associated with central grey and rostral ventromedial medulla
4) Confidence 0.33 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.28 Pain Relevance 1.55
regime elicits differential expression of the immediate early gene c-fos in the ventrolateral PAG in rats in
Negative_regulation (elicits) of Gene_expression (expression) of PAG associated with periaqueductal grey
5) Confidence 0.19 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 1.65 Pain Relevance 0.97
tone in the PAG in females is reduced during LD [19] and also in oestrus, although the latter effect
Negative_regulation (reduced) of Gene_expression (tone) of PAG associated with periaqueductal grey
6) Confidence 0.19 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 0.66 Pain Relevance 0.69
left hemisphere CeA-PAG evoked
Negative_regulation (hemisphere) of Gene_expression (evoked) of PAG associated with central grey and amygdala
7) Confidence 0.05 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.42 Pain Relevance 0.29
Further studies examining CREB and pCREB expression in lateral PAG at 1–3 days post HSV injection are required to
Spec (examining) Negative_regulation (examining) of Gene_expression (expression) of PAG in lateral associated with cold sores and central grey
8) Confidence 0.05 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.07 Pain Relevance 0.30
Green flourescence in the right PAG verified gene expression of GFP occurred after HSV injection in the vicinity of
Negative_regulation (flourescence) of Gene_expression (expression) of PAG associated with cold sores and central grey
9) Confidence 0.05 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.80 Pain Relevance 0.23

General Comments

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