INT254567

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 29
Disease Relevance 31.15
Pain Relevance 24.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PAG1) plasma membrane (PAG1) intracellular (PAG1)
Anatomy Link Frequency
neurons 12
output neurons 6
dorsal 4
lateral 2
lateral column 2
PAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 2397 100.00 Very High Very High Very High
amygdala 1110 100.00 Very High Very High Very High
Rostral ventromedial medulla 408 100.00 Very High Very High Very High
nMDA receptor 228 100.00 Very High Very High Very High
Periaqueductal grey 86 100.00 Very High Very High Very High
Morphine 632 99.98 Very High Very High Very High
Opioid 80 99.56 Very High Very High Very High
antinociception 72 99.04 Very High Very High Very High
IPN 32 98.48 Very High Very High Very High
tolerance 104 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2653 100.00 Very High Very High Very High
Cold Sores 399 100.00 Very High Very High Very High
Stress 1897 99.98 Very High Very High Very High
Inflammatory Pain 40 98.48 Very High Very High Very High
Anxiety Disorder 585 98.08 Very High Very High Very High
Depression 38 97.60 Very High Very High Very High
Pain 277 96.56 Very High Very High Very High
Hyperalgesia 44 94.76 High High
INFLAMMATION 32 88.80 High High
Nociception 22 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
direct activation of PAG output neurons should produce greater antinociception
Positive_regulation (activation) of Gene_expression (output neurons) of PAG in output neurons associated with antinociception and central grey
1) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.14 Pain Relevance 2.12
ventrolateral PAG of males, but only half as many PAG-RVM output neurons were
Positive_regulation (many) of Gene_expression (output neurons) of PAG-RVM in output neurons associated with central grey and rostral ventromedial medulla
2) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.60 Pain Relevance 1.53
morphine action in the PAG were conducted exclusively in males; therefore it
Positive_regulation (conducted) of Gene_expression (action) of PAG associated with central grey and morphine
3) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.13 Pain Relevance 1.44
PAG-RVM neurons were activated by morphine in females suggests that morphine
Positive_regulation (activated) of Gene_expression (neurons) of PAG-RVM in neurons associated with central grey, morphine and rostral ventromedial medulla
4) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.22 Pain Relevance 2.07
in the activation of PAG neurons by morphine (see the black circles in Figures
Positive_regulation (activation) of Gene_expression (neurons) of PAG in neurons associated with central grey and morphine
5) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.33 Pain Relevance 1.84
PAG-RVM neurons in males were activated by morphine, whereas only 20% were
Positive_regulation (activated) of Gene_expression (neurons) of PAG-RVM in neurons associated with central grey, morphine and rostral ventromedial medulla
6) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.27 Pain Relevance 1.94
PAG-RVM output neurons, thereby potentially resulting in a dimorphic response
Positive_regulation (resulting) of Gene_expression (output neurons) of PAG-RVM in output neurons associated with central grey and rostral ventromedial medulla
7) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.00 Pain Relevance 1.70
To examine the activation of PAG-RVM neurons during
Spec (examine) Positive_regulation (activation) of Gene_expression (neurons) of PAG-RVM in neurons associated with central grey and rostral ventromedial medulla
8) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.59 Pain Relevance 2.01
regime elicits differential expression of the immediate early gene c-fos in the ventrolateral PAG in rats in
Positive_regulation (immediate) of Gene_expression (rats) of PAG associated with periaqueductal grey
9) Confidence 0.23 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 1.64 Pain Relevance 0.97
regime elicits differential expression of the immediate early gene c-fos in the ventrolateral PAG in rats in
Positive_regulation (immediate) of Gene_expression (early) of PAG associated with periaqueductal grey
10) Confidence 0.23 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 1.63 Pain Relevance 0.96
Moreover, given that predator stress induces NMDA receptor-dependent right PAG pCREB expression, it has also been suggested
Positive_regulation (induces) of Gene_expression (expression) of PAG associated with stress, nmda receptor and central grey
11) Confidence 0.10 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.45 Pain Relevance 0.86
Moreover, given that predator stress induces NMDA receptor-dependent right PAG pCREB expression, it has also been suggested
Positive_regulation (right) of Gene_expression (expression) of PAG associated with stress, nmda receptor and central grey
12) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.43 Pain Relevance 0.85
separate portions of the CeA-PAG pathway mediate the stress induced changes in startle amplitude and startle
Positive_regulation (-) of Gene_expression (pathway) of PAG associated with stress, central grey and amygdala
13) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.09 Pain Relevance 0.43
potentiation in the right CeA-PAG pathway two days after predator stress (Figure 4), complementing those studies
Positive_regulation (potentiation) of Gene_expression (pathway) of PAG associated with stress, central grey and amygdala
14) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.32 Pain Relevance 0.81
We transfected the neurons of the right PAG in an area where pCREB levels and CeA-PAG transmission are elevated after predator
Positive_regulation (elevated) of Gene_expression (transmission) of PAG in neurons associated with central grey
15) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.12 Pain Relevance 0.34
separate portions of the CeA-PAG pathway mediate the stress induced changes in startle amplitude and startle
Positive_regulation (portions) of Gene_expression (pathway) of PAG associated with stress, central grey and amygdala
16) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.09 Pain Relevance 0.43
We transfected the neurons of the right PAG in an area where pCREB levels and CeA-PAG transmission are elevated after predator
Positive_regulation (-) of Gene_expression (transmission) of PAG in neurons associated with central grey
17) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.12 Pain Relevance 0.34
Moreover, given that predator stress induces NMDA receptor-dependent right PAG pCREB expression, it has also been suggested
Positive_regulation (dependent) of Gene_expression (expression) of PAG associated with stress, nmda receptor and central grey
18) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.44 Pain Relevance 0.85
Injection of HSV-CREB in the right PAG alone was also
Positive_regulation (Injection) of Gene_expression (Injection) of PAG associated with cold sores and central grey
19) Confidence 0.06 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.87 Pain Relevance 0.14
column of the PAG over an AP plane
Positive_regulation (over) of Gene_expression (column) of PAG associated with central grey
20) Confidence 0.06 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.94 Pain Relevance 0.27

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