INT25463

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Context Info
Confidence 0.38
First Reported 1983
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.75
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joint 2
body 2
MRXS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 152 100.00 Very High Very High Very High
cINOD 53 99.98 Very High Very High Very High
antagonist 4 99.76 Very High Very High Very High
aspirin 15 98.80 Very High Very High Very High
corticosteroid 3 97.08 Very High Very High Very High
cOX1 1 85.92 High High
COX2 3 85.28 High High
agonist 8 68.12 Quite High
cytokine 14 56.04 Quite High
ischemia 2 34.04 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 161 100.00 Very High Very High Very High
Disease 135 99.54 Very High Very High Very High
Hypersensitivity 6 99.32 Very High Very High Very High
Mouth Cancer 1 98.00 Very High Very High Very High
Wound Healing 3 96.64 Very High Very High Very High
Cyst 1 94.64 High High
Periodontal Disease 1 94.12 High High
Apoptosis 3 93.32 High High
Respiratory Disease 1 93.12 High High
Increased Venous Pressure Under Development 9 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies have shown that anti-inflammatory drugs block the synthesis of PGs, and antagonists competitively inhibit the action of these compounds in the body.
Negative_regulation (block) of Gene_expression (synthesis) of PGs in body associated with inflammation, antagonist and cinod
1) Confidence 0.38 Published 1989 Journal Zhonghua Ya Yi Xue Hui Za Zhi Section Abstract Doc Link 2701289 Disease Relevance 0.65 Pain Relevance 0.19
The high concentrations of pro-inflammatory prostaglandins (PGs) produced in the joint during the initial stage of inflammation can be decreased by inhibiting their biosynthesis with nonsteroidal anti-inflammatory drugs (NSAIDs).
Negative_regulation (decreased) of Gene_expression (produced) of PGs in joint associated with inflammation and cinod
2) Confidence 0.37 Published 1989 Journal Clin. Rheumatol. Section Abstract Doc Link 2525980 Disease Relevance 0.43 Pain Relevance 0.48
The discovery in 1971 that acetylsalicylic acid and a series of other nonsteroidal anti-inflammatory drugs inhibit the biosynthesis of PGs provided an explanation for the analgetic, antipyretic, and anti-inflammatory activity of these drugs and formed a rational base for their use in a variety of pathological situations believed to involve PGs.
Negative_regulation (inhibit) of Gene_expression (biosynthesis) of PGs associated with aspirin, inflammation and cinod
3) Confidence 0.37 Published 1983 Journal Acta Clin Belg Section Abstract Doc Link 6868938 Disease Relevance 0.69 Pain Relevance 0.20
Gallbladder segments treated with LC did not show a decreased production of any of the three PGs whereas 5-HETE released to the medium was significantly lower.
Negative_regulation (decreased) of Gene_expression (production) of PGs
4) Confidence 0.23 Published 2000 Journal Medicina (B Aires) Section Abstract Doc Link 11188896 Disease Relevance 0.13 Pain Relevance 0.13
Although indomethacin and aspirin are known to suppress allergic and inflammatory reactions, they inhibit the production of all PGs including cytoprotective and anti-inflammatory PGs (Takeuchi et al., 2001 ?
Negative_regulation (inhibit) of Gene_expression (production) of PGs associated with aspirin, inflammation and hypersensitivity
5) Confidence 0.05 Published 2011 Journal Journal of Synchrotron Radiation Section Body Doc Link PMC3004263 Disease Relevance 0.64 Pain Relevance 0.28
Thus, it can be seen that the role of COX and inhibition of PG synthesis in AD pathology is complex; inhibiting the production of PGs with protective/anti-inflammatory properties might be more detrimental for chronic AD pathogenic events than preventing the effects of proinflammatory PGs.
Negative_regulation (inhibiting) of Gene_expression (production) of PGs associated with inflammation and disease
6) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 1.09 Pain Relevance 0.27
Corticosteroids, the potent anti-inflammatory agents elicit their action by blocking the enzyme phospholipase A2 to inhibit arachidonic acid production, thereby preventing the synthesis of all the PGs, thromboxanes and eicosanoids.
Negative_regulation (preventing) of Gene_expression (synthesis) of PGs associated with corticosteroid and inflammation
7) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2751374 Disease Relevance 1.12 Pain Relevance 0.57

General Comments

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