INT254634

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.64
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) signal transduction (Bdkrb2) plasma membrane (Bdkrb2)
signal transducer activity (Bdkrb2)
Anatomy Link Frequency
brains 2
Bdkrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
b2 receptor 46 100.00 Very High Very High Very High
Nicotine 96 99.98 Very High Very High Very High
Inflammation 47 98.20 Very High Very High Very High
bradykinin 53 94.32 High High
B1 receptor 10 87.64 High High
cytokine 11 82.92 Quite High
antagonist 12 76.68 Quite High
Multiple sclerosis 14 59.92 Quite High
Central nervous system 19 51.32 Quite High
chemokine 21 50.00 Quite Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 86 98.36 Very High Very High Very High
INFLAMMATION 51 98.20 Very High Very High Very High
Nicotine Addiction 12 93.20 High High
Brain Injury 1 92.72 High High
Asthma 15 90.60 High High
Adhesions 14 71.60 Quite High
Disease 17 67.16 Quite High
Recurrence 1 22.64 Low Low
Cv General 4 Under Development 4 5.00 Very Low Very Low Very Low
Paralysis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to these B1-dependent effects, B2 receptor activation is necessary for the production of CCL2 in brains of EAE mice.
Positive_regulation (necessary) of Positive_regulation (activation) of B2 receptor in brains associated with multiple sclerosis and b2 receptor
1) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.27 Pain Relevance 0.51
The presented study demonstrated for the first time that long-term exposure (for 4 days) of mouse tracheal segments to nicotine causes a concentration-dependent increase of kinin B1 and B2 receptor-mediated airway contractions.
Positive_regulation (causes) of Positive_regulation (increase) of B2 receptor associated with nicotine and b2 receptor
2) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.36 Pain Relevance 0.62

General Comments

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