INT254636

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.15
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) extracellular space (Ccl2) signal transduction (Bdkrb2)
extracellular region (Ccl2) plasma membrane (Bdkrb2) cytoskeleton organization (Ccl2)
Anatomy Link Frequency
leukocyte 2
Bdkrb2 (Mus musculus)
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 20 100.00 Very High Very High Very High
Inflammation 24 97.64 Very High Very High Very High
Central nervous system 19 96.52 Very High Very High Very High
b2 receptor 17 75.00 Quite High
Multiple sclerosis 14 41.92 Quite Low
bradykinin 12 5.00 Very Low Very Low Very Low
Spinal cord 11 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 86 99.70 Very High Very High Very High
INFLAMMATION 28 97.64 Very High Very High Very High
Disease 15 83.52 Quite High
Targeted Disruption 4 67.48 Quite High
Adhesions 13 48.32 Quite Low
Cv General 4 Under Development 4 5.00 Very Low Very Low Very Low
Paralysis 4 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low
Weight Loss 2 5.00 Very Low Very Low Very Low
Immunization 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that B2 receptors have two major effects in the control of EAE severity: (i) B2 regulates the expression of chemokines, including CCL2 and CCL5, and (ii) B2 modulates leukocyte recruitment and inflammatory lesions in the CNS.



B2 Regulation (regulates) of Gene_expression (expression) of CCL2 in leukocyte associated with chemokine, multiple sclerosis, inflammation and central nervous system
1) Confidence 0.15 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2596102 Disease Relevance 1.15 Pain Relevance 0.43

General Comments

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