INT25464

Context Info Confidence 0.42 First Reported 1989 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 11 Total Number 12 Disease Relevance 6.89 Pain Relevance 3.72

extracellular region (SAA1)

Anatomy Link Frequency plasma 1 spinal 1 liver 1 SAA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Arachnoiditis 5 100.00 Paracetamol 27 99.92 diclofenac 57 99.54 Codeine 108 92.84 Hippocampus 14 92.72 cINOD 11 87.00 Arthritis 4 86.08 Angina 5 85.48 Cauda equina syndrome 2 85.36 abdominal pain 3 85.00

Disease Link Frequency Relevance Heat Alzheimer's Dementia 5 100.00 Arachnoiditis 5 100.00 Hydrocephalus 3 100.00 Disease 111 99.76 Fever 86 99.76 Amyloidosis 3 98.92 Pancreatic Cancer 49 98.80 Obesity 71 97.16 Insulin Resistance 6 96.96 Diabetes Mellitus 21 95.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To our knowledge, the association between hydrocephalus and postoperative spinal adhesive arachnoiditis (SAA) has never been reported.

SAA Binding (association) of in spinal associated with arachnoiditis and hydrocephalus

1) Confidence 0.42 Published 2008 Journal Clin Neurol Neurosurg Section Abstract Doc Link 17950992 Disease Relevance 0.97 Pain Relevance 0.66

The SAA1-alpha/alpha genotype was associated with an increased risk of amyloidosis.

SAA1 Binding (associated) of associated with amyloidosis

2) Confidence 0.36 Published 2003 Journal Pediatr. Nephrol. Section Abstract Doc Link 12836090 Disease Relevance 1.48 Pain Relevance 0.21

Variations in plasma sulfur amino acid (SAA) pools are associated with disease risks, but little information is available about the factors affecting plasma SAA pools.

SAA Binding (associated) of in plasma associated with disease

3) Confidence 0.33 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20207721 Disease Relevance 0.10 Pain Relevance 0.33

The results suggest a need to evaluate possible effects of APAP in association with SAA insufficiency as a contributing factor in disease risk.

SAA Binding (association) of associated with paracetamol and disease

4) Confidence 0.31 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20207721 Disease Relevance 0.10 Pain Relevance 1.04

Serum concentrations of C-reactive protein (CRP) and serum amyloid A (SAA) were substantially elevated in patients with fever (Table 2 and Additional File 2, Figure S1) which is typical for the syndrome.

SAA Binding (concentrations) of associated with syndrome, alzheimer's dementia and fever

5) Confidence 0.22 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 1.04 Pain Relevance 0.04

The determination of CRP and SAA was performed by means of immunonephelometry with the Behring Nephelometer Analyzer II (BNII).

SAA Spec (determination) Binding (determination) of

6) Confidence 0.20 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.16 Pain Relevance 0.03

It has been speculated that the interaction between the SAA1 protein and the putative receptor SELS [6] could be involved in the development of insulin resistance, and a recent study in rats showed that the expression level of SELS in liver was higher in diabetic rats compared with both healthy rats and diabetic rats treated with the insulin sensitizer rosiglitazone [25].

SAA1 protein Binding (interaction) of in liver associated with diabetes mellitus and insulin resistance

7) Confidence 0.17 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.45 Pain Relevance 0

By 1.2 hours after ingestion of a 200 mg dose, the maximum serum concentration (Cmax) averaged 15.9 micrograms/ml, with more than 99% of the drug bound to serum protein.

serum protein Binding (bound) of

8) Confidence 0.05 Published 1989 Journal Clin. Rheumatol. Section Abstract Doc Link 2525981 Disease Relevance 0.25 Pain Relevance 0.12

In addition, diclofenac is known to be highly bound to serum protein (>99.7%).[31] Therefore it is likely that diclofenac, at least after administration of a common single dose, does not achieve serum levels fast enough and high enough to inhibit codeine glucuronidation in vivo.

serum protein Binding (bound) of associated with diclofenac and codeine

9) Confidence 0.03 Published 2002 Journal BMC Clin Pharmacol Section Body Doc Link PMC101395 Disease Relevance 0 Pain Relevance 1.02

In contrast to Serum 6, Serum 1 shows strong binding to the pinceau (green arrows in D) colocalizing with Lgi1 (insets in D show the pinceau at higher magnification).

Serum 1 Binding (binding) of

10) Confidence 0.01 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.26 Pain Relevance 0.11

In contrast, Serum 1 (B) binds to the mf more than the rad, colocalizing with Lgi1.

Serum 1 Binding (binds) of

11) Confidence 0.01 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.31 Pain Relevance 0.16

MBL2 is a calcium-dependent serum protein that plays a role in the innate immune response by binding to carbohydrates on the surface of a wide range of pathogens including viruses, bacteria, fungi, and protozoa where it can activate the complement system or act directly as an opsonin [17,18].

serum protein Binding (binding) of

12) Confidence 0.00 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.78 Pain Relevance 0

General Comments

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