INT254667

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.98
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k2) kinase activity (Map2k2)
Anatomy Link Frequency
IEC-6 4
Map2k2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 28 79.28 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Perioperative pain 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intestinal Cancer 32 99.28 Very High Very High Very High
Cancer 144 97.20 Very High Very High Very High
Metastasis 40 96.32 Very High Very High Very High
Colon Cancer 180 96.28 Very High Very High Very High
Injury 4 93.00 High High
Stress 6 91.88 High High
Apoptosis 33 71.88 Quite High
Adenocarcinoma 32 63.32 Quite High
Death 25 58.40 Quite High
Adhesions 8 56.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of wild type MEK1 or MEK2 did not affect the expression of endogenous MEK isoforms.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of MEK2
1) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.41 Pain Relevance 0
The activation levels of ERK, the p38 target MK-2 and the JNK target c-jun in cell lysates were assessed by immunoblotting with phospho-specific antibodies.
Positive_regulation (activation) of Gene_expression (levels) of MK-2
2) Confidence 0.49 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.07 Pain Relevance 0
Of the 69 gene transcripts that showed altered expression in the study of Komatsu, 18 (26%) were found to be modulated in IEC-6 cells expressing constitutively active MEK1 or MEK2.
Positive_regulation (active) of Gene_expression (expressing) of MEK2 in IEC-6
3) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.43 Pain Relevance 0.07
Ectopic expression of activated MEK1 or MEK2 significantly enhanced the invasive capacity of IEC-6 cells, while the wild type MEK isoforms had no effect (Fig. 3B).
Positive_regulation (enhanced) of Gene_expression (expression) of MEK2 in IEC-6
4) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.48 Pain Relevance 0
Here, we show that expression of activated MEK1 or MEK2 not only induces the formation of intestinal tumors but also promotes later stages of tumor progression and metastasis to distant organs.
Positive_regulation (induces) of Gene_expression (expression) of MEK2 associated with cancer, intestinal cancer and metastasis
5) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 1.58 Pain Relevance 0

General Comments

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