INT25467

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.00
First Reported 1989
Last Reported 2008
Negated 4
Speculated 2
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 8.68
Pain Relevance 6.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rab38) vesicle-mediated transport (Rab38) Golgi apparatus (Rab38)
endoplasmic reticulum (Rab38) GTPase activity (Rab38) cytoplasm (Rab38)
Anatomy Link Frequency
neurons 3
blood 2
sensory neurons 1
liver 1
colon 1
Rab38 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 14 100.00 Very High Very High Very High
tetrodotoxin 12 100.00 Very High Very High Very High
Glutamate 11 100.00 Very High Very High Very High
nMDA receptor 36 99.88 Very High Very High Very High
electroacupuncture 9 99.70 Very High Very High Very High
Pain 5 99.52 Very High Very High Very High
Kinase C 5 99.32 Very High Very High Very High
dorsal root ganglion 33 99.20 Very High Very High Very High
addiction 1 98.68 Very High Very High Very High
Serotonin 1 98.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 40 100.00 Very High Very High Very High
Cv General 3 Under Development 14 100.00 Very High Very High Very High
Pain 5 99.52 Very High Very High Very High
Diabetes Mellitus 6 98.12 Very High Very High Very High
Hyperalgesia 2 97.68 Very High Very High Very High
Injury 120 97.36 Very High Very High Very High
Body Weight 68 97.28 Very High Very High Very High
INFLAMMATION 16 96.96 Very High Very High Very High
Coronary Stenosis 2 96.24 Very High Very High Very High
Urological Neuroanatomy 34 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EA alone did not change [Glu] in the rVLM (n = 6, P > 0.05).
Neg (not) Regulation (change) of rVLM associated with glutamate and electroacupuncture
1) Confidence 0.00 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17158649 Disease Relevance 0 Pain Relevance 1.33
However, these results do suggest modulation of TTX-R I(Na) in colonic afferents is an underlying mechanism of hyperalgesia and pain associated with inflammation of the colon and that this current constitutes a novel target for therapeutic relief of visceral inflammatory pain.
Regulation (modulation) of TTX-R in colon associated with pain, hyperalgesia, inflammation and ipn
2) Confidence 0.17 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12205171 Disease Relevance 0.95 Pain Relevance 0.57
Prostaglandin E(2) modulates TTX-R I(Na) in rat colonic sensory neurons.
Regulation (modulates) of TTX-R in sensory neurons
3) Confidence 0.17 Published 2002 Journal J. Neurophysiol. Section Title Doc Link 12205171 Disease Relevance 0.59 Pain Relevance 0.39
The small GTP-binding protein Rho and its downstream effector, Rho-kinase, are important regulators of vasoconstrictor tone.
Regulation (regulators) of small GTP-binding protein Rho
4) Confidence 0.15 Published 2008 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 18689606 Disease Relevance 0.39 Pain Relevance 0.03
These results suggest that the basal TTX-R I(Na) obtained from neonatal NG neurons is controlled by the level of PKC activity.
Regulation (controlled) of TTX-R in neurons associated with ganglion cysts and kinase c
5) Confidence 0.09 Published 2005 Journal Life Sci. Section Abstract Doc Link 16111720 Disease Relevance 0.31 Pain Relevance 0.26
M and its effects on SPW-R activity were studied with recordings made from the CA1 field.
Regulation (effects) of SPW-R
6) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0.08 Pain Relevance 0.10
To clarify the modulation of dragon's blood on the tetrodotoxin-resistant (TTX-R) sodium currents in dorsal root ganglion (DRG) neurons and explore its corresponding material basis for the efficacy, using whole-cell patch clamp technique, the effects of dragon's blood and the combined effects of three components (cochinchinenin A, cochinchinenin B, and loureirin B) extracted from dragon's blood on the TTX-R sodium currents in acute-isolated DRG neurons of rats were observed.
Regulation (modulation) of TTX-R in blood associated with ganglion cysts, dorsal root ganglion and tetrodotoxin
7) Confidence 0.04 Published 2006 Journal Sci. China, C, Life Sci. Section Abstract Doc Link 16856497 Disease Relevance 0.41 Pain Relevance 0.38
Although the three components used alone could modulate TTX-R sodium currents, the concentrations of the three components used alone were respectively higher than those used in combination when the inhibition rates on the TTX-R sodium currents of them used alone and in combination were the same.
Regulation (modulate) of TTX-R
8) Confidence 0.04 Published 2006 Journal Sci. China, C, Life Sci. Section Abstract Doc Link 16856497 Disease Relevance 0.47 Pain Relevance 0.46
These results suggested that the interference with pain messages caused by the modulation of dragon's blood on TTX-R sodium currents in DRG neurons may explain some of the analgesic effect of dragon's blood and the corresponding material basis for the efficacy is the combination of cochinchinenin A, cochinchinenin B, and loureirin B.
Regulation (modulation) of TTX-R in blood associated with dorsal root ganglion, pain and analgesic
9) Confidence 0.04 Published 2006 Journal Sci. China, C, Life Sci. Section Abstract Doc Link 16856497 Disease Relevance 0.39 Pain Relevance 0.42
TTX-R Na(v)1.9 sodium current was also significantly increased, whereas no alteration of TTX-R Na(v)1.8 current was observed in neurons from diabetic rats.
Neg (no) Regulation (alteration) of TTX-R in neurons associated with diabetes mellitus
10) Confidence 0.03 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16310161 Disease Relevance 0.68 Pain Relevance 0.31
Thiopental effects on in vitro SPW-R complexes
Regulation (effects) of SPW-R
11) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0 Pain Relevance 0
The distinct effects of the two drugs on SPW-R activity, achieved at clinically relevant concentrations, resemble their differing sedative and amnesic effects.
Regulation (effects) of SPW-R
12) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0 Pain Relevance 0.11
However, conditions facilitating NMDA receptor activation, such as low magnesium medium, or direct exogenous activation of NMDA receptors, may affect SPW-R activity [64].
Spec (may) Regulation (affect) of SPW-R associated with nmda receptor
13) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0 Pain Relevance 0.22
We hypothesize that the thiopental-induced effects on SPW-R activity are implicated in the drug-induced impairment of hippocampus-involving memory processes.


Regulation (effects) of SPW-R in hippocampus associated with hippocampus
14) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0.18 Pain Relevance 0.11
We show that at clinically relevant concentrations the two drugs differently affect SPW-R complexes, with thiopental strongly affecting activity and phenobarbital displaying no significant effects.


Regulation (affect) of SPW-R
15) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0.17 Pain Relevance 0.04
Tetrodotoxin-resistant (TTX-R) sodium current in small-size dorsal root ganglia (DRG) neurons is upregulated by prostaglandin E(2) and serotonin through a protein kinase A (PKA)/protein kinase (PKC) pathway, suggesting G protein modulation of one or more TTX-R channels in these neurons.
Regulation (modulation) of TTX-R in neurons associated with tetrodotoxin and serotonin
16) Confidence 0.02 Published 2003 Journal Exp Brain Res Section Abstract Doc Link 12898089 Disease Relevance 0 Pain Relevance 0.22
We also examined the effect of TJ-10 administration on the hepatic activities of antioxidant enzymes such as SOD, catalase, Se-GSHpx, GSSG-R, and glucose-6-phosphate dehydrogenase (G-6-PDH), an enzyme to produce NAPDH using glucose-6-phospahte, with liver injury progression in ANIT-treated rats.


Spec (examined) Regulation (effect) of GSSG-R in liver associated with injury
17) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.94 Pain Relevance 0
The same doses of TJ-10 administered to ANIT-untreated rats did not affect hepatic SOD, catalase, Se-GSHpx, and GSSG-R activities but the herbal medicine administered at a dose 2.6 g/kg BW caused a significant increase in hepatic G-6-PDH activity.
Neg (not) Regulation (affect) of GSSG-R associated with body weight
18) Confidence 0.00 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.91 Pain Relevance 0.06
No effects were observed on TTX-R I(Na).
Neg (No) Regulation (effects) of TTX-R
19) Confidence 0.00 Published 2006 Journal Brain Res. Section Abstract Doc Link 16914123 Disease Relevance 0 Pain Relevance 0.29
Therefore, rW-R was regulated with coronary flow in EAP.
Regulation (regulated) of rW-R associated with angina
20) Confidence 0.00 Published 1989 Journal Kaku Igaku Section Abstract Doc Link 2526266 Disease Relevance 1.13 Pain Relevance 0.72

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox