INT254671

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.83
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Map2k1) cytoplasm (Map2k1) cytosol (Map2k1)
cell proliferation (Map2k1) mitosis (Map2k1) cell motility (Map2k1)
Anatomy Link Frequency
IEC-6 1
Map2k1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 28 80.72 Quite High
cytokine 13 62.96 Quite High
isoflurane 5 5.00 Very Low Very Low Very Low
Perioperative pain 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 23 94.48 High High
Colon Cancer 180 93.04 High High
Intestinal Cancer 32 90.96 High High
Coronary Heart Disease 3 90.56 High High
Metastasis 40 74.60 Quite High
Acute Myocarditis 1 73.68 Quite High
Cancer 145 73.16 Quite High
Sudden Death 1 71.92 Quite High
Apoptosis 37 64.52 Quite High
Enterovirus Infection 1 63.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown by immunoblot analysis, lentivirus-mediated delivery of MEK1 shRNAs resulted in complete silencing of MEK1 expression with no effect on MEK2, whereas the two MEK2 shRNAs markedly knocked-down MEK2 expression without affecting MEK1 isoform (Fig. 6B).
Neg (without) Regulation (affecting) of MEK1
1) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.12 Pain Relevance 0
Analysis of the gene expression data identified several genes that were up-regulated or down-regulated in MEK1DD- and MEK2DD-expressing cells as compared to control IEC-6 cells (Additional files 1 and 2).
Regulation (regulated) of MEK1DD in IEC-6
2) Confidence 0.32 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.44 Pain Relevance 0.11
We tested the effect of 5 distinct shRNAs for MEK1 and 3 shRNAs for MEK2, using as control a GFP-encoding vector.
Regulation (effect) of MEK1
3) Confidence 0.32 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.37 Pain Relevance 0
Furthermore, it has been reported that the MEK1 pathway is involved in upregulation of nNOS transcription under some circumstances [75].
Regulation (involved) of MEK1
4) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.45 Pain Relevance 0.03
To assess the individual roles of MEK1 and MEK2, we expressed short-hairpin (sh) RNAs specifically targeting MEK1 or MEK2 gene in HCT116 cells using VSV-pseudotyped lentiviral vectors.
Regulation (targeting) of MEK1
5) Confidence 0.19 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.44 Pain Relevance 0

General Comments

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