INT254672

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k2) kinase activity (Map2k2)
Anatomy Link Frequency
colon 2
Map2k2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 14 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 90 98.16 Very High Very High Very High
Apoptosis 16 97.76 Very High Very High Very High
Adhesions 4 43.48 Quite Low
Death 4 42.36 Quite Low
Metastasis 20 38.64 Quite Low
Cancer 72 31.68 Quite Low
Targeted Disruption 8 23.60 Low Low
Adenocarcinoma 16 5.00 Very Low Very Low Very Low
Intestinal Cancer 16 5.00 Very Low Very Low Very Low
Infection 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Strikingly, lowering of MEK2 expression with the two shRNAs completely suppressed the proliferation of HCT116 cells, whereas MEK1 shRNAs exerted a significant but much weaker effect (Fig. 6B).
Negative_regulation (lowering) of Gene_expression (expression) of MEK2
1) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.11 Pain Relevance 0
Silencing of MEK2 expression markedly inhibits the proliferation of human colon cancer cells
Negative_regulation (Silencing) of Gene_expression (expression) of MEK2 in colon associated with colon cancer
2) Confidence 0.34 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.66 Pain Relevance 0

General Comments

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