INT254675

Context Info Confidence 0.36 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.85 Pain Relevance 0.20

cytosol (Map2k2) kinase activity (Map2k2)

Map2k2 (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 14 97.36 Perioperative pain 2 5.00 isoflurane 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 16 98.80 Cancer 72 90.56 Colon Cancer 90 86.48 Intestinal Cancer 16 57.32 Adhesions 4 48.92 Death 4 47.80 Metastasis 20 44.08 Injury 2 11.16 Adenocarcinoma 16 5.00 Infection 14 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, activation of either MEK1 or MEK2 markedly up-regulated the expression of MMP-13 protein (Fig. 4A).

Regulation (regulated) of Positive_regulation (activation) of MEK2

1) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.20 Pain Relevance 0.20

MEK1 or MEK2 activation had no significant effect on the expression of the pro-apoptotic proteins Bax and Bak in these cells (data not shown).

Neg (no) Regulation (effect) of Positive_regulation (activation) of MEK2 associated with apoptosis

2) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.66 Pain Relevance 0

General Comments

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