INT254677

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k2) kinase activity (Map2k2)
Anatomy Link Frequency
colon 2
Map2k2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 7 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 8 98.68 Very High Very High Very High
Cancer 36 92.44 High High
Respiratory Distress 1 83.56 Quite High
Weight Loss 1 82.68 Quite High
Intestinal Cancer 8 76.64 Quite High
Colon Cancer 45 75.68 Quite High
Injury 1 37.20 Quite Low
Metastasis 10 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these data demonstrate that constitutive activation of MEK1 or MEK2 is sufficient to transform intestinal epithelial cells and induce the formation of invasive colon adenocarcinomas.


Positive_regulation (induce) of Positive_regulation (activation) of MEK2 in colon associated with adenocarcinoma
1) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.94 Pain Relevance 0

General Comments

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